Astl - astacin-like metalloendopeptidase (M12 family) Gene

Also Known as Sas1b; 7420700F21

Species: Mus musculus

Gene Type: protein coding
Gene ID: 215095

Summary

Enables aspartic-type peptidase activity and glutamic-type peptidase activity. Involved in several processes, including negative regulation of binding activity of sperm to zona pellucida; positive regulation of protein processing; and prevention of polyspermy. Located in cortical granule and plasma membrane. Is expressed in early conceptus and oocyte. Orthologous to human ASTL (astacin like metalloendopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Astl Products (2)

mRNA Protein Name
NM_001291003.1 NP_001277932.1 astacin-like metalloendopeptidase isoform a precursor
NM_172539.3 NP_766127.1 astacin-like metalloendopeptidase isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aspartic-type peptidase activity IDA
IDA: Inferred from direct assay
22472438 MGI
enables glutamic-type peptidase activity IDA
IDA: Inferred from direct assay
22472438 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
22206759 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22206759 MGI
Biological Process GO Annotation Evidence References Source
involved in cell adhesion IMP
IMP: Inferred from mutant phenotype
22206759 MGI
involved in fertilization IMP
IMP: Inferred from mutant phenotype
22206759 MGI
involved in negative regulation of binding of sperm to zona pellucida IDA
IDA: Inferred from direct assay
22472438 MGI
involved in positive regulation of protein processing IDA
IDA: Inferred from direct assay
22472438 MGI
involved in prevention of polyspermy IDA
IDA: Inferred from direct assay
22472438 MGI
Cellular Component GO Annotation Evidence References Source
located in cortical granule IDA
IDA: Inferred from direct assay
22472438 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
22206759 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
22206759 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

astacin-like metalloendopeptidase

  • oocyte astacin

  • ovastacin

  • sperm acrosomal SLLP1

  • sperm acrosomal SLLP1-binding protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01111 ASTL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18601 Astl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25086 Astl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Astl NCBI NCBI:431705