ASTL - astacin like metalloendopeptidase Gene

Also Known as SAS1B; OOMD11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 431705

About ASTL

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,122,818-96,138,564 (from NCBI)

This gene has 2 transcripts (splice variants), 210 orthologues, 35 paralogues and is associated with 1 phenotype. Biased expression in bone marrow (RPKM 1.1), skin (RPKM 0.2) and 10 other tissues.

Summary

Predicted to enable aspartic-type peptidase activity; glutamic-type peptidase activity; and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of binding activity of sperm to zona pellucida; positive regulation of protein processing; and prevention of polyspermy. Predicted to be located in cortical granule and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ASTL Products (1)

mRNA Protein Name
NM_001002036.4 NP_001002036.3 astacin-like metalloendopeptidase precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASTL Protein Structure

Astacin

Astacin: Astacin (Peptidase family M12A) (103 - 282)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

astacin-like metalloendopeptidase

  • ZP2-proteinase

ASTL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ASTL Q6HA08 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
ASTL Q6HA08 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Oocyte Maturation Defect 11

  • OOMD11
Colorado Tick Fever

  • Mountain Tick Fever

  • Tick Fever, American Mountain

  • American Mountain Fever

  • Colorado Tick Encephalitis

  • Colorado Tick-Borne Disease

  • Mountain Fever

  • American Mountain Tick Fever

  • Colorado Tick-Borne Fever

  • Colorado Tick Fever Virus

  • Non-Exanthematous Tick Fever
Powassan Encephalitis

  • Powassan Encephalitis Virus Infection
Anisakiasis

  • Infection By Anisakis Larva

  • Anisakis Infection

  • Pseudoterranova Infection

  • Anisakiasis Due To Anisakis Simplex

  • Anisakiasis Due To Pseudoterranova Decipiens

  • Anisakis Infestation

  • Infection Due To Anisakis Larvae
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01111 ASTL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18601 Astl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25086 Astl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ASTL RGD RGD:1562279
Mus musculus ASTL MGD MGI:3046414
Macaca mulatta ASTL VGNC VGNC:106129
Felis catus ASTL VGNC VGNC:59982
Bos taurus ASTL VGNC VGNC:26226
Others ASTL NCBI