ASTL - astacin like metalloendopeptidase Gene

Homo sapiens

Also known as SAS1B; OOMD11

Gene ID: 431705 | Gene type: protein coding

About ASTL

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,122,818-96,138,564 (from NCBI)

This gene has 2 transcripts (splice variants), 210 orthologues, 35 paralogues and is associated with 1 phenotype. Biased expression in bone marrow (RPKM 1.1), skin (RPKM 0.2) and 10 other tissues.

Summary

Predicted to enable aspartic-type peptidase activity; glutamic-type peptidase activity; and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of binding activity of sperm to zona pellucida; positive regulation of protein processing; and prevention of polyspermy. Predicted to be located in cortical granule and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ASTL Products(1)

mRNA	Protein	Name
NM_001002036.4	NP_001002036.3	astacin-like metalloendopeptidase precursor

ASTL Protein Structure

Astacin

0
100
200
300
400
431 a.a.

Protein Preferred Names

Protein Names

astacin-like metalloendopeptidase

ZP2-proteinase

Related Diseases

Diseases

Alias

Oocyte Maturation Defect 11

OOMD11

Colorado Tick Fever

Mountain Tick Fever	Tick Fever, American Mountain
American Mountain Fever	Colorado Tick Encephalitis
Colorado Tick-Borne Disease	Mountain Fever
American Mountain Tick Fever	Colorado Tick-Borne Fever
Colorado Tick Fever Virus	Non-Exanthematous Tick Fever

Powassan Encephalitis

Powassan Encephalitis Virus Infection

Anisakiasis

Infection By Anisakis Larva	Anisakis Infection
Pseudoterranova Infection	Anisakiasis Due To Anisakis Simplex
Anisakiasis Due To Pseudoterranova Decipiens	Anisakis Infestation
Infection Due To Anisakis Larvae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01111	ASTL Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ASTL	RGD	RGD:1562279
Mus musculus	ASTL	MGD	MGI:3046414
Macaca mulatta	ASTL	VGNC	VGNC:106129
Felis catus	ASTL	VGNC	VGNC:59982
Bos taurus	ASTL	VGNC	VGNC:26226
Others	ASTL	NCBI