2. Gene
  3. Hip1 - huntingtin interacting protein 1 Gene

Hip1 - huntingtin interacting protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mKIAA4113; 2610109B09Rik; A930014B11Rik; E130315I21Rik

Gene ID: 215114 | Gene type: protein coding

About Hip1

Summary

Predicted to enable several functions, including clathrin binding activity; phosphatidylinositol phosphate binding activity; and protein dimerization activity. Involved in endocytosis and positive regulation of receptor-mediated endocytosis. Predicted to be located in Golgi apparatus and postsynapse. Predicted to be extrinsic component of cytoplasmic side of plasma membrane and extrinsic component of presynaptic membrane. Predicted to be active in clathrin-coated vesicle and presynapse. Predicted to be extrinsic component of postsynaptic membrane. Is expressed in brain; cerebral cortex; embryo; telencephalon; and testis. Orthologous to human HIP1 (Huntingtin interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Hip1 Products(2)

mRNA Protein Name
NM_001382848.1 NP_001369777.1 huntingtin-interacting protein 1 isoform 2
NM_146001.2 NP_666113.2 huntingtin-interacting protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12839988 MGI
Biological Process GO Annotation Evidence Reference Source
involved in endocytosis IDA
IDA: Inferred from direct assay
11604514 MGI
involved in positive regulation of receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
11577110 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
17928447 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
17928447 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
12839988 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
12839988 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
17928447 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
17928447 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12839988 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
12839988 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

huntingtin-interacting protein 1

HIP-I

huntingtin-interacting protein I

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107551 Hh Pathway-IN-1 99.06% Unkown
HY-RS12742 SETD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179558 MS1-96 Degrader / Unkown
HY-P3799 [Glp6] Substance P (6-11) / Unkown
HY-RS06179 HIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06180 HIP1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hip1 NCBI NCBI:3092