Agap2 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Gene

Also Known as PIKE; AGAP-2; Centg1; cnt-g1; mKIAA0167

Species: Mus musculus

Gene Type: protein coding

Gene ID: 216439

Summary

The protein encoded by this gene is a member of the centaurin GTPase family. This gene product regulates the activity of multiple kinases, including PI3K. Reduced expression of this gene results in multiple defects, including neural deficiencies, while increased expression of this gene has been observed in some tumors. Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]

Agap2 Products (2)

mRNA	Protein	Name
NM_001033263.5	NP_001028435.1	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform 1
NM_001301014.1	NP_001287943.1	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20075866	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	20075866	MGI
acts upstream of cell surface receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	20075866	MGI
acts upstream of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20075866	MGI
acts upstream of or within mammary gland alveolus development	IMP IMP: Inferred from mutant phenotype	20075866	MGI
acts upstream of mammary gland epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	20075866	MGI
acts upstream of mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	20075866	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16841086	MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20075866	MGI
acts upstream of or within positive regulation of mammary gland epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	20075866	MGI
acts upstream of or within positive regulation of mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	20075866	MGI
acts upstream of or within positive regulation of receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	20075866	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20075866	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28706196	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	28706196	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	28706196	MGI
is active in postsynapse	IEP IEP: Inferred from expression pattern	28706196	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	centaurin, gamma 1 phosphatidylinositol 3-kinase enhancer

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00438	AGAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Agap2	NCBI	NCBI:116986