2. Gene
  3. Mars1 - methionine-tRNA synthetase 1 Gene

Mars1 - methionine-tRNA synthetase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mars; Metrs; Mtrns

Gene ID: 216443 | Gene type: protein coding

About Mars1

Summary

The encoded protein belongs to the class I family of tRNA synthetases, a class of Enzymes that charge tRNAs with their cognate Amino acids. The related human gene product is essential for the translation initiation of mRNAs. This gene has an overlapping 3' UTR tail-to-tail arrangement with an adjacent gene on the opposite strand that encodes an inhibitor of the CCAAT/enhancer-binding protein's DNA binding activity. This arrangement, conserved in human and mouse, may be involved in mRNA stability and possible functional and regulatory interaction of these adjacent overlapping genes. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]

Mars1 Products(2)

mRNA Protein Name
NM_001003913.2 NP_001003913.1 methionine--tRNA ligase, cytoplasmic isoform 2
NM_001171582.1 NP_001165053.1 methionine--tRNA ligase, cytoplasmic isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables methionine-tRNA ligase activity IMP
IMP: Inferred from mutant phenotype
12060739 MGI
Biological Process GO Annotation Evidence Reference Source
involved in methionyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
12060739 MGI
Cellular Component GO Annotation Evidence Reference Source
part of aminoacyl-tRNA synthetase multienzyme complex IDA
IDA: Inferred from direct assay
12060739 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

methionine--tRNA ligase, cytoplasmic

methionine tRNA ligase

methionyl-tRNA synthetase, cytoplasmic

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08153 MARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mars1 NCBI NCBI:4141