Phf1 - PHD finger protein 1 Gene

Also Known as Pcl1; Phf2; Tctex3; D17Ertd455e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21652

Summary

The protein encoded by this gene belongs to the polycomb-like protein family, which is a component of polycomb repressive complex-2. This complex represses gene expression by catalyzing the trimethylation of histone H3 lysine 27 and is required for the regulation of developmental genes including homeotic genes. The gene is expressed primarily in testis tissue. Small interfering RNA-mediated knockdown in cultured cell lines results in changes in homeotic gene expression coincident with alterations in promoter methylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Phf1 Products (2)

mRNA Protein Name
NM_001302397.1 NP_001289326.1 PHD finger protein 1 isoform 2
NM_009343.3 NP_033369.2 PHD finger protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables methylated histone binding IDA
IDA: Inferred from direct assay
23104054 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11559747 MGI
Cellular Component GO Annotation Evidence References Source
part of ESC/E(Z) complex IDA
IDA: Inferred from direct assay
31451685 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

PHD finger protein 1

  • polycomb-like protein 1

  • t-complex testis-expressed 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181914 UNC7242 Antagonist / Unkown
HY-RS10413 PHF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phf1 NCBI NCBI:5252