2. Gene
  3. Phf1 - PHD finger protein 1 Gene

Phf1 - PHD finger protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pcl1; Phf2; Tctex3; D17Ertd455e

Gene ID: 21652 | Gene type: protein coding

About Phf1

Summary

The protein encoded by this gene belongs to the polycomb-like protein family, which is a component of polycomb repressive complex-2. This complex represses gene expression by catalyzing the trimethylation of histone H3 lysine 27 and is required for the regulation of developmental genes including homeotic genes. The gene is expressed primarily in testis tissue. Small interfering RNA-mediated knockdown in cultured cell lines results in changes in homeotic gene expression coincident with alterations in promoter methylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Phf1 Products(2)

mRNA Protein Name
NM_001302397.1 NP_001289326.1 PHD finger protein 1 isoform 2
NM_009343.3 NP_033369.2 PHD finger protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables methylated histone binding IDA
IDA: Inferred from direct assay
23104054 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11559747 MGI
Cellular Component GO Annotation Evidence Reference Source
part of ESC/E(Z) complex IDA
IDA: Inferred from direct assay
31451685 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

PHD finger protein 1

polycomb-like protein 1

t-complex testis-expressed 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-181914 UNC7242 Antagonist / Unkown
HY-RS10413 PHF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phf1 NCBI NCBI:5252