Arhgap44 - Rho GTPase activating protein 44 Gene

Also Known as Rich2; 6330543G20

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216831

Summary

Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including modification of dendritic spine; negative regulation of Rac protein signal transduction; and neurotransmitter receptor transport, endosome to postsynaptic membrane. Located in dendritic spine. Is active in glutamatergic synapse. Is expressed in central nervous system; olfactory epithelium; respiratory system; and retina. Orthologous to human ARHGAP44 (Rho GTPase activating protein 44). [provided by Alliance of Genome Resources, Apr 2022]

Arhgap44 Products (12)

mRNA Protein Name
NM_001099288.2 NP_001092758.1 rho GTPase-activating protein 44 isoform 1
NM_001408223.1 NP_001395152.1 rho GTPase-activating protein 44 isoform 3
NM_001408224.1 NP_001395153.1 rho GTPase-activating protein 44 isoform 4
NM_001408226.1 NP_001395155.1 rho GTPase-activating protein 44 isoform 5
NM_001408228.1 NP_001395157.1 rho GTPase-activating protein 44 isoform 6
NM_175003.4 NP_778168.2 rho GTPase-activating protein 44 isoform 2
NM_001099288.2 NP_001092758.1 rho GTPase-activating protein 44 isoform 1
NM_001408223.1 NP_001395152.1 rho GTPase-activating protein 44 isoform 3
NM_001408224.1 NP_001395153.1 rho GTPase-activating protein 44 isoform 4
NM_001408226.1 NP_001395155.1 rho GTPase-activating protein 44 isoform 5
NM_001408228.1 NP_001395157.1 rho GTPase-activating protein 44 isoform 6
NM_175003.4 NP_778168.2 rho GTPase-activating protein 44 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
24352656 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
24352656 MGI
Biological Process GO Annotation Evidence References Source
involved in modification of postsynaptic structure IDA
IDA: Inferred from direct assay
23739967 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
23739967 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
23739967 MGI
involved in negative regulation of Rac protein signal transduction IMP
IMP: Inferred from mutant phenotype
24352656 MGI
involved in regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
24352656 MGI
involved in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IDA
IDA: Inferred from direct assay
23739967 MGI
involved in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
23739967 MGI
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
24352656 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23739967 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23739967 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho GTPase-activating protein 44

  • RICH-2

  • Rho GTPase-activating protein RICH2

  • Rho-type GTPase-activating protein RICH2

  • RhoGAP interacting with CIP4 homologs protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00937 ARHGAP44 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arhgap44 NCBI NCBI:9912