Wrap53 - WD repeat containing, antisense to Trp53 Gene

Also Known as Wdr79

Species: Mus musculus

Gene Type: protein coding

Gene ID: 216853

Summary

Predicted to enable several functions, including chaperone binding activity; Telomerase RNA binding activity; and ubiquitin protein Ligase binding activity. Involved in positive regulation of Telomerase activity. Predicted to be located in cytosol; nuclear body; and site of double-strand break. Predicted to be part of Telomerase holoenzyme complex. Predicted to be active in Cajal body. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 3; colorectal cancer; head and neck squamous cell carcinoma; lung non-small cell carcinoma; and ovarian Cancer. Orthologous to human WRAP53 (WD repeat containing antisense to TP53). [provided by Alliance of Genome Resources, Apr 2022]

Wrap53 Products (2)

mRNA	Protein	Name
NM_001364769.1	NP_001351698.1	telomerase Cajal body protein 1
NM_144824.3	NP_659073.1	telomerase Cajal body protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables RNA folding chaperone	IDA IDA: Inferred from direct assay	29804836	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
telomerase Cajal body protein 1	WD repeat containing, antisense to TP53 WD repeat domain 79 WD repeat-containing protein 79 WD repeat-containing protein WRAP53 WD40 repeat-containing protein antisense to TP53 gene homolog WD40 repeat-containing protein encoded by RNA antisense to p

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15846	WRAP53 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wrap53	NCBI	NCBI:55135