Kctd11 - potassium channel tetramerisation domain containing 11 Gene

Mus musculus

Also known as Ren

Gene ID: 216858 | Gene type: protein coding

About Kctd11

Summary

Predicted to enable identical protein binding activity. Acts upstream of or within negative regulation of neuroblast proliferation; negative regulation of smoothened signaling pathway; and positive regulation of neuron differentiation. Located in cytoplasm. Is expressed in several structures, including 1st branchial arch; central nervous system; ectoplacental cone; primitive streak; and sensory organ. Orthologous to human KCTD11 (Potassium Channel tetramerization domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]

Kctd11 Products(1)

mRNA	Protein	Name
NM_153143.4	NP_694783.1	BTB/POZ domain-containing protein KCTD11

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of neuroblast proliferation	IDA IDA: Inferred from direct assay	16148242	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IDA IDA: Inferred from direct assay	16148242	MGI
acts upstream of or within nervous system development	IDA IDA: Inferred from direct assay	12186855	MGI
acts upstream of neuroblast differentiation	IDA IDA: Inferred from direct assay	16148242	MGI
acts upstream of neuroblast proliferation	IDA IDA: Inferred from direct assay	16148242	MGI
acts upstream of neuron differentiation	IDA IDA: Inferred from direct assay	16148242	MGI
acts upstream of or within neuron differentiation	IDA IDA: Inferred from direct assay	12186855	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	16148242	MGI
acts upstream of or within regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12186855	MGI
acts upstream of smoothened signaling pathway	IDA IDA: Inferred from direct assay	16148242	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12186855	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

BTB/POZ domain-containing protein KCTD11

KCASH1 protein	RING-type E3 ubiquitin transferase KCTD11
RING-type E3 ubiquitin transferase subunit KCTD11	potassium channel tetramerization domain-containing protein 11
retinoic acid, EGF, and NGF upregulated

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07188	KCTD11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kctd11	NCBI	NCBI:147040

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