2. Gene
  3. Nle1 - notchless homolog 1 Gene

Nle1 - notchless homolog 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nle; l11Jus1; l11Jus4

Gene ID: 217011 | Gene type: protein coding

About Nle1

Summary

Acts upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and regulation of signal transduction. Located in nucleolus. Is expressed in several structures, including 2-cell stage embryo; gonad; hemolymphoid system gland; inner cell mass; and liver. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Apr 2022]

Nle1 Products(1)

mRNA Protein Name
NM_145431.2 NP_663406.2 notchless protein homolog 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
16611995 MGI
acts upstream of or within Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
23231322 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
24062412 MGI
acts upstream of or within inner cell mass cell differentiation IMP
IMP: Inferred from mutant phenotype
16611995 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
24875805 MGI
acts upstream of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
24062412 MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
23231322 MGI
acts upstream of or within negative regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
24062412 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
23231322 MGI
acts upstream of or within ribosomal large subunit biogenesis IMP
IMP: Inferred from mutant phenotype
24062412 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
24824078 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
24875805 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleolus IDA
IDA: Inferred from direct assay
24081661 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

notchless protein homolog 1

Notchless gene homolog

novel WD40 repeat containing protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09338 NLE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nle1 NCBI NCBI:54475