Nploc4 - NPL4 homolog, ubiquitin recognition factor Gene

Also Known as Npl4; mKIAA1499

Species: Mus musculus

Gene Type: protein coding
Gene ID: 217365

Summary

Predicted to enable ATPase binding activity; ubiquitin binding activity; and ubiquitin protein Ligase binding activity. Predicted to contribute to K48-linked polyubiquitin modification-dependent protein binding activity and K63-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and proteolysis involved in cellular protein catabolic process. Predicted to be located in cytosol. Predicted to be part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. Predicted to be active in nucleus. Orthologous to human NPLOC4 (NPL4 homolog, ubiquitin recognition factor). [provided by Alliance of Genome Resources, Apr 2022]

Nploc4 Products (2)

mRNA Protein Name
NM_001195023.1 NP_001181952.1 nuclear protein localization protein 4 homolog isoform A
NM_199469.2 NP_955763.1 nuclear protein localization protein 4 homolog isoform B

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway EXP
EXP: Inferred from Experiment
12847084 MGI
involved in retrograde protein transport, ER to cytosol EXP
EXP: Inferred from Experiment
12847084 MGI
Cellular Component GO Annotation Evidence References Source
part of VCP-NPL4-UFD1 AAA ATPase complex EXP
EXP: Inferred from Experiment
22232657 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear protein localization protein 4 homolog

  • nuclear protein localization 4 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09489 NPLOC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nploc4 NCBI NCBI:55666