2. Gene
  3. Nploc4 - NPL4 homolog, ubiquitin recognition factor Gene

Nploc4 - NPL4 homolog, ubiquitin recognition factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Npl4; mKIAA1499

Gene ID: 217365 | Gene type: protein coding

About Nploc4

Summary

Predicted to enable ATPase binding activity; ubiquitin binding activity; and ubiquitin protein Ligase binding activity. Predicted to contribute to K48-linked polyubiquitin modification-dependent protein binding activity and K63-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and proteolysis involved in cellular protein catabolic process. Predicted to be located in cytosol. Predicted to be part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. Predicted to be active in nucleus. Orthologous to human NPLOC4 (NPL4 homolog, ubiquitin recognition factor). [provided by Alliance of Genome Resources, Apr 2022]

Nploc4 Products(2)

mRNA Protein Name
NM_001195023.1 NP_001181952.1 nuclear protein localization protein 4 homolog isoform A
NM_199469.2 NP_955763.1 nuclear protein localization protein 4 homolog isoform B
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in ERAD pathway EXP
EXP: Inferred from Experiment
12847084 MGI
involved in retrograde protein transport, ER to cytosol EXP
EXP: Inferred from Experiment
12847084 MGI
Cellular Component GO Annotation Evidence Reference Source
part of VCP-NPL4-UFD1 AAA ATPase complex EXP
EXP: Inferred from Experiment
22232657 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear protein localization protein 4 homolog

nuclear protein localization 4 homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09489 NPLOC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nploc4 NCBI NCBI:55666