FANCE - FA complementation group E Gene

Homo sapiens

Also known as FAE; FACE

Gene ID: 2178 | Gene type: protein coding

About FANCE

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,452,338-35,467,102 (from NCBI)

This gene has 8 transcripts (splice variants), 190 orthologues and is associated with 52 phenotypes. Broad expression in placenta (RPKM 5.1), testis (RPKM 5.0) and 24 other tissues.

Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. [provided by RefSeq, Jul 2008]

FANCE Products(2)

mRNA	Protein	Name
NM_001410876.1	NP_001397805.1	Fanconi anemia group E protein isoform 2
NM_021922.3	NP_068741.1	Fanconi anemia group E protein isoform 1

FANCE Protein Structure

FA_FANCE

0
100
200
300
400
500
536 a.a.

Protein Preferred Names

Protein Names

Fanconi anemia group E protein

Fanconi anemia complementation group E

Related Diseases

Diseases

Alias

Fanconi Anemia, Complementation Group E

Fanconi Anemia Complementation Group E	FANCE
Face	Faces Syndrome

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Fanconi Anemia, Complementation Group O

Fanconi Anemia Complementation Group O

FANCO

Fanconi Anemia, Complementation Group B

Fanconi Anemia Complementation Group B	FANCB
Facb	Fa2
Fanconi Pancytopenia Type 2	Fanconi Pancytopenia, Type 2

Colorectal Cancer, Hereditary Nonpolyposis, Type 4

HNPCC4	Hereditary Nonpolyposis Colorectal Cancer Type 4
Hereditary Non-Polyposis Colorectal Cancer 4	Cancer, Colorectal, Nonpolyposis, Hereditary, Type 4

Fanconi Anemia, Complementation Group Q

Fanconi Anemia Complementation Group Q

FANCQ

Familial Adenomatous Polyposis 1

Gardner Syndrome	Brain Tumor-Polyposis Syndrome 2
Familial Polyposis Of The Colon	Adenomatous Polyposis Coli
FAP1	Adenomatous Polyposis Of The Colon
Apc	Fpc
Gardner'S Syndrome	Polyposis, Adenomatous Intestinal
Adenoma, Periampullary, Somatic	Intestinal Polyposis, Osteomas, Sebaceous Cysts
Polyposis Coli And Multiple Hard And Soft Tissue Tumors	Apc-Related Attenuated Familial Adenomatous Polyposis
Apc-Related Afap	Apc-Related Attenuated Fap
Apc-Related Attenuated Familial Polyposis Coli	Turcot Syndrome With Polyposis
Gardners Syndrome	Adenomatous Polyposis Coli, Susceptibility To
Adenomatous Polyposis, Familial, Type 1

Fanconi Anemia, Complementation Group D1

Fanconi Anemia Complementation Group D1	FANCD1
Fad1	Inherited Cancer-Predisposing Syndrome Due To Biallelic Brca2 Mutations

Fanconi Anemia, Complementation Group F

Fanconi Anemia Complementation Group F

FANCF

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Fanconi Anemia, Complementation Group I

Fanconi Anemia Complementation Group I

FANCI

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Physical Disorder

Physical Illness

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04736	FANCE Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FANCE	VGNC	VGNC:72610
Bos taurus	FANCE	VGNC	VGNC:28856
Rattus norvegicus	FANCE	RGD	RGD:1561045
Canis familiaris	FANCE	VGNC	VGNC:40720
Felis catus	FANCE	VGNC	VGNC:62143
Mus musculus	FANCE	MGD	MGI:1920025

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