Tia1 - cytotoxic granule-associated RNA binding protein 1 Gene

Also Known as TIA-1; mTIA-1; 2310050N03Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21841

Summary

Enables mRNA 3'-UTR AU-rich region binding activity. Acts upstream of or within negative regulation of cytokine production and negative regulation of translation. Located in cytoplasmic stress granule and nuclear stress granule. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Tia1 Products (3)

mRNA	Protein	Name
NM_001164078.1	NP_001157550.1	cytotoxic granule associated RNA binding protein TIA1 isoform 2
NM_001164079.1	NP_001157551.1	cytotoxic granule associated RNA binding protein TIA1 isoform 3
NM_011585.4	NP_035715.1	cytotoxic granule associated RNA binding protein TIA1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	10921895	MGI
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	16227602	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	10921895	MGI
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	16227602	MGI
acts upstream of or within negative regulation of translation	IMP IMP: Inferred from mutant phenotype	10921895	MGI
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	10938105	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11514562	MGI
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	21933836	MGI
located in nuclear stress granule	IDA IDA: Inferred from direct assay	22022532	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12388085	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cytotoxic granule associated RNA binding protein TIA1 nucleolysin TIA-1	RNA-binding protein TIA-1 T-cell-restricted intracellular antigen-1

Protein Preferred Names

Protein Names

cytotoxic granule associated RNA binding protein TIA1

nucleolysin TIA-1

RNA-binding protein TIA-1
T-cell-restricted intracellular antigen-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-185357	TAU-IN-6	Inhibitor	/	Unkown
HY-RS14513	TIA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20825	Tia1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27339	Tia1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tia1	NCBI	NCBI:7072