Pde8b - phosphodiesterase 8B Gene

Also Known as B230331L10Rik; C030047E14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 218461

Summary

Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within several processes, including behavioral fear response; learning; and negative regulation of steroid hormone biosynthetic process. Is expressed in several structures, including alimentary system; central nervous system; hindlimb digit; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE8B (phosphodiesterase 8B). [provided by Alliance of Genome Resources, Apr 2022]

Pde8b Products (17)

mRNA Protein Name
NM_001170669.2 NP_001164140.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 1
NM_001346782.2 NP_001333711.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 3
NM_001374003.1 NP_001360932.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 4
NM_001374004.1 NP_001360933.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 5
NM_001374005.1 NP_001360934.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 6
NM_001374006.1 NP_001360935.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 7
NM_001374007.1 NP_001360936.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 8
NM_001404688.1 NP_001391617.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 9
NM_001404689.1 NP_001391618.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 10
NM_001404690.1 NP_001391619.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 11
NM_001404691.1 NP_001391620.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 12
NM_001404692.1 NP_001391621.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 13
NM_001404693.1 NP_001391622.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 14
NM_001404694.1 NP_001391623.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 15
NM_001404695.1 NP_001391624.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 16
NM_001404696.1 NP_001391625.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 17
NM_172263.3 NP_758467.2 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
21187369 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
22925203 MGI
acts upstream of or within negative regulation of steroid hormone biosynthetic process IMP
IMP: Inferred from mutant phenotype
21187369 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
22925203 MGI
acts upstream of or within operant conditioning IMP
IMP: Inferred from mutant phenotype
22925203 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
22925203 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

  • cell proliferation-inducing gene 22 protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15426 PF-04957325 Inhibitor 99.55% Unkown
HY-135711 PDE8B-IN-1 99.91% Unkown
HY-117848 PDE8B-IN-1 hydrochloride Inhibitor / Unkown
HY-RS10245 PDE8B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde8b NCBI NCBI:8622