Ttc5 - tetratricopeptide repeat domain 5 Gene

Mus musculus

Gene ID: 219022 | Gene type: protein coding

About Ttc5

Summary

Enables DNA binding activity and chromatin binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Orthologous to human TTC5 (tetratricopeptide repeat domain 5). [provided by Alliance of Genome Resources, Apr 2022]

Ttc5 Products(3)

mRNA	Protein	Name
NM_001080949.2	NP_001074418.1	tetratricopeptide repeat protein 5 isoform a
NM_001360545.1	NP_001347474.1	tetratricopeptide repeat protein 5 isoform c
NM_177625.4	NP_808293.1	tetratricopeptide repeat protein 5 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	22362889	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	22362889	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11511361	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	18833288	MGI
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	15448695	MGI
involved in cellular response to starvation	IMP IMP: Inferred from mutant phenotype	30420355	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22362889	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22362889	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	30420355	MGI
located in cytosol	IDA IDA: Inferred from direct assay	15448695	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	25168243	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15448695	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tetratricopeptide repeat protein 5

TPR repeat protein 5	protein Strap
stress-responsive activator of p300

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15216	TTC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ttc5	NCBI	NCBI:91875

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