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Nr2e1 - nuclear receptor subfamily 2, group E, member 1 Gene

Also Known as TLL; Tlx; frc; Mtl1; Mtll; XTLL; fierce; tailless

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21907

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Involved in positive regulation of stem cell proliferation. Acts upstream of or within several processes, including forebrain development; regulation of neural precursor cell proliferation; and regulation of neuron differentiation. Located in nucleus. Is expressed in several structures, including heart; nervous system; sensory organ; skeleton; and urinary system. Orthologous to human NR2E1 (nuclear receptor subfamily 2 group E member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr2e1 Products (1)

mRNA	Protein	Name
NM_152229.3	NP_689415.1	nuclear receptor subfamily 2 group E member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19555662	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	14702088	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	10706625	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16702404	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	20123967	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	20123967	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16702404	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within aggressive behavior	IMP IMP: Inferred from mutant phenotype	12527005	MGI
acts upstream of or within amygdala development	IMP IMP: Inferred from mutant phenotype	12527005	MGI
acts upstream of angiogenesis	IMP IMP: Inferred from mutant phenotype	16424942	MGI
acts upstream of or within anterior commissure morphogenesis	IMP IMP: Inferred from mutant phenotype	11997145	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	16702404	MGI
acts upstream of or within astrocyte cell migration	IMP IMP: Inferred from mutant phenotype	15371513	MGI
acts upstream of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	14702088	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	12527005	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	14994267	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	15371513	MGI
acts upstream of cell cycle	IMP IMP: Inferred from mutant phenotype	17901127	MGI
acts upstream of or within cell fate commitment	IGI IGI: Inferred from genetic interaction	15229646	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	14702088	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	11997145	MGI
acts upstream of or within cerebral cortex neuron differentiation	IMP IMP: Inferred from mutant phenotype	12902391	MGI
acts upstream of or within dentate gyrus development	IMP IMP: Inferred from mutant phenotype	12527005	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	16424942	MGI
acts upstream of or within forebrain generation of neurons	IMP IMP: Inferred from mutant phenotype	9394001	MGI
acts upstream of or within layer formation in cerebral cortex	IMP IMP: Inferred from mutant phenotype	15385616	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	16289828	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16702404	MGI
acts upstream of or within negative regulation of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	14702088	MGI
acts upstream of or within negative regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	12527005	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	12527005	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14702088	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10706625	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20123967	MGI
acts upstream of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	12527005	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16702404	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	12527005	MGI
acts upstream of or within olfactory bulb development	IMP IMP: Inferred from mutant phenotype	11997145	MGI
acts upstream of or within positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	16424942	MGI
acts upstream of or within positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	17901127	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	14702088	MGI
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	20123967	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16702404	MGI
involved in positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	20123967	MGI
acts upstream of or within regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	16424942	MGI
acts upstream of or within regulation of cellular component organization	IMP IMP: Inferred from mutant phenotype	16424942	MGI
acts upstream of or within regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	16289828	MGI
acts upstream of or within regulation of timing of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15385616	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	11997145	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	11997145	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	12527005	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	10706625	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	17901127	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nuclear receptor subfamily 2 group E member 1	nuclear receptor TLX protein tailless homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135572	TLX agonist 1	Modulator	99.94%	Unkown
HY-180403	TLX agonist 3	Agonist	/	Unkown
HY-RS09539	NR2E1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr2e1	NCBI	NCBI:7101