UNC5B - unc-5 netrin receptor B Gene

Also Known as UNC5H2; p53RDL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 219699

About UNC5B

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:71,212,570-71,302,864 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 4.8), gall bladder (RPKM 4.7) and 24 other tissues.

Summary

This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in Cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

UNC5B Products (2)

mRNA Protein Name
NM_001244889.2 NP_001231818.1 netrin receptor UNC5B isoform 2 precursor
NM_170744.5 NP_734465.2 netrin receptor UNC5B isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18469807 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
18469807 GOA
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18469807 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
18469807 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNC5B Protein Structure

I-set

I-set: Immunoglobulin I-set domain (154 - 243)

TSP_1

TSP_1: Thrombospondin type 1 domain (250 - 296)

TSP_1

TSP_1: Thrombospondin type 1 domain (306 - 353)

ZU5

ZU5: ZU5 domain (543 - 643)

Death

Death: Death domain (864 - 936)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 945 a.a.
Protein Preferred Names Protein Names

netrin receptor UNC5B

  • p53-regulated receptor for death and life protein 1

UNC5B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
UNC5B Q8IZJ1 Agap2 Rattus norvegicus Q8CGU4
Anti Tag CoIP
18469807
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UNC5B Proteins

Cat. No. Product Name Accession Purity
HY-P74481 UNC5B Protein, Human (HEK293, His) Q8IZJ1 (G27-P363) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74482 UNC5B Protein, Human (HEK293, hFc) Q8IZJ1-1 (G27-P363) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15472 UNC5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18193 Unc5b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24667 Unc5b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991624 Anti-UNC5B Antibody (YW88) Inhibitor 95.17% Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UNC5B VGNC VGNC:78722
Bos taurus UNC5B VGNC VGNC:36671
Felis catus UNC5B VGNC VGNC:66829
Rattus norvegicus UNC5B RGD RGD:621756
Mus musculus UNC5B MGD MGI:894703
Canis familiaris UNC5B VGNC VGNC:48140
Others UNC5B NCBI