2. Gene
  3. Tpst2 - protein-tyrosine sulfotransferase 2 Gene

Tpst2 - protein-tyrosine sulfotransferase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as grm; grt; D5Ucla3; Tango13b

Gene ID: 22022 | Gene type: protein coding

About Tpst2

Summary

Enables protein-tyrosine sulfotransferase activity. Acts upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization; peptidyl-tyrosine sulfation; and prevention of polyspermy. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi apparatus. Orthologous to human TPST2 (tyrosylprotein sulfotransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tpst2 Products(4)

mRNA Protein Name
NM_001326590.2 NP_001313519.2 protein-tyrosine sulfotransferase 2 precursor
NM_001374708.1 NP_001361637.1 protein-tyrosine sulfotransferase 2 precursor
NM_001374709.1 NP_001361638.1 protein-tyrosine sulfotransferase 2 precursor
NM_009419.5 NP_033445.3 protein-tyrosine sulfotransferase 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein-tyrosine sulfotransferase activity IDA
IDA: Inferred from direct assay
9733778 MGI
enables protein-tyrosine sulfotransferase activity IMP
IMP: Inferred from mutant phenotype
17046811 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization IMP
IMP: Inferred from mutant phenotype
21339297 MGI
involved in peptidyl-tyrosine sulfation IDA
IDA: Inferred from direct assay
9733778 MGI
acts upstream of or within peptidyl-tyrosine sulfation IMP
IMP: Inferred from mutant phenotype
17046811 MGI
acts upstream of or within prevention of polyspermy IMP
IMP: Inferred from mutant phenotype
21339297 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in Golgi lumen IDA
IDA: Inferred from direct assay
3121635 MGI
is active in trans-Golgi network IDA
IDA: Inferred from direct assay
3121635 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein-tyrosine sulfotransferase 2

TPST-2

tyrosylprotein sulfotransferase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-179288 TPST2-IN-1 Inhibitor / Unkown
HY-E70190 Tyrosylprotein Sulfotransferase 2 Activator / Unkown
HY-RS14955 TPST2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpst2 NCBI NCBI:8459