Traip - TRAF-interacting protein Gene

Also Known as Trip

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22036

Summary

Enables ubiquitin protein Ligase activity. Involved in negative regulation of interferon-beta production and protein ubiquitination. Acts upstream of or within negative regulation of NF-kappaB transcription factor activity and signal transduction. Predicted to be located in nucleolus; nucleoplasm; and site of DNA damage. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina layer; and spleen. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Traip Products (5)

mRNA Protein Name
NM_001410470.1 NP_001397399.1 E3 ubiquitin-protein ligase TRAIP isoform 2
NM_001410471.1 NP_001397400.1 E3 ubiquitin-protein ligase TRAIP isoform 3
NM_001410472.1 NP_001397401.1 E3 ubiquitin-protein ligase TRAIP isoform 4
NM_001410473.1 NP_001397402.1 E3 ubiquitin-protein ligase TRAIP isoform 4
NM_011634.4 NP_035764.2 E3 ubiquitin-protein ligase TRAIP isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9104814 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
17544371 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
17544371 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
9109628 MGI
involved in negative regulation of interferon-beta production IDA
IDA: Inferred from direct assay
22945920 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
17544371 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
9104814 MGI
acts upstream of or within signal transduction IPI
IPI: Inferred from physical interaction
9104814 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRAIP

  • RING-type E3 ubiquitin transferase TRAIP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14978 TRAIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Traip NCBI NCBI:10293