Trpc2 - transient receptor potential cation channel, subfamily C, member 2 Gene

Also Known as trp2; Trrp2; mTrp2; TRPC2a; TRPC2b; smTRPC2; 3010009O07Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22064

Summary

Enables several functions, including Calmodulin binding activity; diacylglycerol binding activity; and inositol 1,4,5 trisphosphate binding activity. Acts upstream of or within several processes, including inter-male aggressive behavior; mating behavior; and territorial aggressive behavior. Located in several cellular components, including Golgi membrane; dendrite membrane; and nuclear envelope. Is expressed in brain; ganglia; genitourinary system; and sensory organ. Orthologous to human TRPC2 (transient receptor potential cation channel subfamily C member 2 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]

Trpc2 Products (1)

mRNA	Protein	Name
NM_001109897.2	NP_001103367.1	short transient receptor potential channel 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables diacylglycerol binding	IMP IMP: Inferred from mutant phenotype	14642279	MGI
enables inositol 1,4,5 trisphosphate binding	IDA IDA: Inferred from direct assay	14505576	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10051594	MGI
NOT enables store-operated calcium channel activity	IDA IDA: Inferred from direct assay	10998353	MGI
enables store-operated calcium channel activity	IDA IDA: Inferred from direct assay	10051594	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within acrosome reaction	IMP IMP: Inferred from mutant phenotype	11331878	MGI
acts upstream of or within aggressive behavior	IMP IMP: Inferred from mutant phenotype	24828191	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	11331878	MGI
acts upstream of or within female courtship behavior	IMP IMP: Inferred from mutant phenotype	17676034	MGI
acts upstream of or within inter-male aggressive behavior	IMP IMP: Inferred from mutant phenotype	11823606	MGI
acts upstream of or within mating behavior, sex discrimination	IMP IMP: Inferred from mutant phenotype	11823606	MGI
acts upstream of or within negative regulation of male mating behavior	IGI IGI: Inferred from genetic interaction	24089208	MGI
acts upstream of or within positive regulation of cytosolic calcium ion concentration	IPI IPI: Inferred from physical interaction	10051594	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23637329	MGI
acts upstream of or within response to pheromone	IMP IMP: Inferred from mutant phenotype	11823606	MGI
acts upstream of or within territorial aggressive behavior	IMP IMP: Inferred from mutant phenotype	11972034	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite membrane	IMP IMP: Inferred from mutant phenotype	14642279	MGI
located in endomembrane system	IDA IDA: Inferred from direct assay	10998353	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	14699131	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
short transient receptor potential channel 2	transient receptor potential 2-like protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11704	f-MKKFRW	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpc2	NCBI	NCBI:7221