Ttn - titin Gene

Also Known as L56; mdm; shru; 1100001C23Rik; 2310036G12Rik; 2310057K23Rik; 2310074I15Rik; D330041I19Rik; D830007G01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22138

Summary

Enables ankyrin binding activity. Involved in regulation of relaxation of cardiac muscle. Acts upstream of or within several processes, including chordate embryonic development; forward locomotion; and heart development. Located in M band and Z disc. Is expressed in several structures, including diaphragm; embryo mesenchyme; heart; musculature; and tarsus. Used to study autosomal recessive limb-girdle muscular dystrophy type 2J; dilated cardiomyopathy 1G; and tibial muscular dystrophy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human TTN (titin). [provided by Alliance of Genome Resources, Apr 2022]

Ttn Products (3)

mRNA Protein Name
NM_001385708.1 NP_001372637.1 titin isoform 3
NM_011652.3 NP_035782.3 titin isoform N2-A
NM_028004.2 NP_082280.2 titin isoform N2-B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ankyrin binding IPI
IPI: Inferred from physical interaction
18310072 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14741210 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult heart development IMP
IMP: Inferred from mutant phenotype
16702235 MGI
acts upstream of or within cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
17360664 MGI
acts upstream of or within cardiac myofibril assembly IMP
IMP: Inferred from mutant phenotype
16702235 MGI
acts upstream of or within forward locomotion IMP
IMP: Inferred from mutant phenotype
16115818 MGI
involved in heart development IEP
IEP: Inferred from expression pattern
9817758 MGI
acts upstream of or within heart growth IMP
IMP: Inferred from mutant phenotype
17360664 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
16702235 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
16702235 MGI
acts upstream of or within muscle contraction IMP
IMP: Inferred from mutant phenotype
16115818 MGI
involved in regulation of relaxation of cardiac muscle IMP
IMP: Inferred from mutant phenotype
23283722 MGI
acts upstream of or within sarcomere organization IMP
IMP: Inferred from mutant phenotype
16702235 MGI
involved in somitogenesis IEP
IEP: Inferred from expression pattern
9817758 MGI
acts upstream of or within striated muscle cell development IMP
IMP: Inferred from mutant phenotype
16115818 MGI
acts upstream of or within ventricular system development IMP
IMP: Inferred from mutant phenotype
17360664 MGI
Cellular Component GO Annotation Evidence References Source
located in A band IDA
IDA: Inferred from direct assay
16481394 MGI
located in I band IDA
IDA: Inferred from direct assay
16481394 MGI
located in M band IDA
IDA: Inferred from direct assay
15138196 MGI
located in Z disc IDA
IDA: Inferred from direct assay
15138196 MGI
located in sarcomere IDA
IDA: Inferred from direct assay
12651156 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

titin

  • connectin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15238 TTR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15235 TTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18333 Ttn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23458 Dbi Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24812 Ttn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ttn NCBI NCBI:7273