Tulp3 - tubby-like protein 3 Gene

Mus musculus

Also known as 2310022L06Rik

Gene ID: 22158 | Gene type: protein coding

About Tulp3

Summary

Predicted to enable several functions, including enzyme binding activity; intraciliary transport particle A binding activity; and phosphatidylinositol binding activity. Acts upstream of or within several processes, including animal organ development; nervous system development; and regulation of signal transduction. Located in axoneme. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Used to study polycystic kidney disease. Orthologous to human TULP3 (TUB like protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Tulp3 Products(1)

mRNA	Protein	Name
NM_011657.2	NP_035787.1	tubby-related protein 3

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	19334287	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	11406614	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	11406614	MGI
acts upstream of or within bronchus morphogenesis	IMP IMP: Inferred from mutant phenotype	19286674	MGI
acts upstream of or within central nervous system neuron differentiation	IMP IMP: Inferred from mutant phenotype	19286674	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	19286674	MGI
acts upstream of or within embryonic camera-type eye development	IMP IMP: Inferred from mutant phenotype	19286674	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	19286674	MGI
acts upstream of or within embryonic neurocranium morphogenesis	IMP IMP: Inferred from mutant phenotype	19286674	MGI
acts upstream of or within ganglion development	IMP IMP: Inferred from mutant phenotype	11406614	MGI
acts upstream of or within limb development	IGI IGI: Inferred from genetic interaction	19223390	MGI
acts upstream of or within limb development	IMP IMP: Inferred from mutant phenotype	19223390	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	19223390	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	19223390	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	19286674	MGI
acts upstream of or within neural tube formation	IMP IMP: Inferred from mutant phenotype	11406614	MGI
acts upstream of or within protein localization to cilium	IMP IMP: Inferred from mutant phenotype	28154160	MGI
involved in protein localization to cilium	IMP IMP: Inferred from mutant phenotype	31761534	MGI
acts upstream of or within regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28154160	MGI
acts upstream of or within regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	19286674	MGI
acts upstream of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	19223390	MGI
acts upstream of or within smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	19223390	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axoneme	IDA IDA: Inferred from direct assay	19286674	MGI
located in cilium	IDA IDA: Inferred from direct assay	19286674	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tubby-related protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15272	TULP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tulp3	NCBI	NCBI:7289

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