Unc5c - unc-5 netrin receptor C Gene

Also Known as rcm; Unc5h3; B130051O18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22253

Summary

Enables netrin receptor activity involved in chemorepulsion and tubulin binding activity. Involved in chemorepulsion of axon and netrin-activated signaling pathway. Acts upstream of or within nervous system development; positive regulation of apoptotic process; and regulation of cell migration. Located in several cellular components, including filopodium; growth cone; and lamellipodium. Is expressed in several structures, including brain; embryo mesenchyme; ovary; sensory organ; and skeleton. Orthologous to human UNC5C (unc-5 netrin receptor C). [provided by Alliance of Genome Resources, Apr 2022]

Unc5c Products (2)

mRNA Protein Name
NM_001293561.1 NP_001280490.1 netrin receptor UNC5C isoform 1 precursor
NM_009472.4 NP_033498.1 netrin receptor UNC5C isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables netrin receptor activity IDA
IDA: Inferred from direct assay
10964959 MGI
enables netrin receptor activity involved in chemorepulsion IDA
IDA: Inferred from direct assay
22685302 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10964959 MGI
enables tubulin binding IPI
IPI: Inferred from physical interaction
28483977 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior axon guidance IMP
IMP: Inferred from mutant phenotype
18479186 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
18077458 MGI
involved in axon guidance IDA
IDA: Inferred from direct assay
22685302 MGI
acts upstream of or within axon guidance IGI
IGI: Inferred from genetic interaction
23144223 MGI
involved in axon guidance IGI
IGI: Inferred from genetic interaction
22685302 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
1401878 MGI
involved in chemorepulsion of axon IMP
IMP: Inferred from mutant phenotype
28483977 MGI
acts upstream of ectopic germ cell programmed cell death IMP
IMP: Inferred from mutant phenotype
18077458 MGI
involved in netrin-activated signaling pathway IGI
IGI: Inferred from genetic interaction
22685302 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18077458 MGI
acts upstream of or within positive regulation of developmental process IMP
IMP: Inferred from mutant phenotype
18077458 MGI
acts upstream of or within positive regulation of reproductive process IMP
IMP: Inferred from mutant phenotype
18077458 MGI
acts upstream of or within regulation of cell migration IMP
IMP: Inferred from mutant phenotype
10818148 MGI
acts upstream of or within regulation of neuron migration IMP
IMP: Inferred from mutant phenotype
9389662 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
22685302 MGI
located in dendrite IDA
IDA: Inferred from direct assay
22685302 MGI
located in filopodium IDA
IDA: Inferred from direct assay
28483977 MGI
located in growth cone IDA
IDA: Inferred from direct assay
22685302 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
28483977 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
22685302 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10964959 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

netrin receptor UNC5C

  • UNC-5 homolog 3

  • rostral cerebellar malformation protein

  • unc-5 homolog C

  • unc5 homolog 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3882 Fmoc-Ala-Glu-Gln-Lys-NH2 99.26% Unkown
HY-RS15473 UNC5C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Unc5c NCBI NCBI:8633