Unc5c - unc-5 netrin receptor C Gene

Mus musculus

Also known as rcm; Unc5h3; B130051O18Rik

Gene ID: 22253 | Gene type: protein coding

About Unc5c

Summary

Enables netrin receptor activity involved in chemorepulsion and tubulin binding activity. Involved in chemorepulsion of axon and netrin-activated signaling pathway. Acts upstream of or within nervous system development; positive regulation of apoptotic process; and regulation of cell migration. Located in several cellular components, including filopodium; growth cone; and lamellipodium. Is expressed in several structures, including brain; embryo mesenchyme; ovary; sensory organ; and skeleton. Orthologous to human UNC5C (unc-5 netrin receptor C). [provided by Alliance of Genome Resources, Apr 2022]

Unc5c Products(2)

mRNA	Protein	Name
NM_001293561.1	NP_001280490.1	netrin receptor UNC5C isoform 1 precursor
NM_009472.4	NP_033498.1	netrin receptor UNC5C isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables netrin receptor activity	IDA IDA: Inferred from direct assay	10964959	MGI
enables netrin receptor activity involved in chemorepulsion	IDA IDA: Inferred from direct assay	22685302	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10964959	MGI
enables tubulin binding	IPI IPI: Inferred from physical interaction	28483977	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anterior/posterior axon guidance	IMP IMP: Inferred from mutant phenotype	18479186	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	18077458	MGI
involved in axon guidance	IDA IDA: Inferred from direct assay	22685302	MGI
acts upstream of or within axon guidance	IGI IGI: Inferred from genetic interaction	23144223	MGI
involved in axon guidance	IGI IGI: Inferred from genetic interaction	22685302	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	1401878	MGI
involved in chemorepulsion of axon	IMP IMP: Inferred from mutant phenotype	28483977	MGI
acts upstream of ectopic germ cell programmed cell death	IMP IMP: Inferred from mutant phenotype	18077458	MGI
involved in netrin-activated signaling pathway	IGI IGI: Inferred from genetic interaction	22685302	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18077458	MGI
acts upstream of or within positive regulation of developmental process	IMP IMP: Inferred from mutant phenotype	18077458	MGI
acts upstream of or within positive regulation of reproductive process	IMP IMP: Inferred from mutant phenotype	18077458	MGI
acts upstream of or within regulation of cell migration	IMP IMP: Inferred from mutant phenotype	10818148	MGI
acts upstream of or within regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	9389662	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	22685302	MGI
located in dendrite	IDA IDA: Inferred from direct assay	22685302	MGI
located in filopodium	IDA IDA: Inferred from direct assay	28483977	MGI
located in growth cone	IDA IDA: Inferred from direct assay	22685302	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	28483977	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	22685302	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10964959	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

netrin receptor UNC5C

UNC-5 homolog 3	rostral cerebellar malformation protein
unc-5 homolog C	unc5 homolog 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3882	Fmoc-Ala-Glu-Gln-Lys-NH2		99.90%	Unkown
HY-RS15473	UNC5C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Unc5c	NCBI	NCBI:8633

Name
Email *

	Sorry, but the email address you supplied was invalid.