Sox21 - SRY (sex determining region Y)-box 21 Gene

Mus musculus

Also known as Sox25

Gene ID: 223227 | Gene type: protein coding

About Sox21

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within hair follicle development and regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; oral region epithelium; and skin. Orthologous to human SOX21 (SRY-box transcription factor 21). [provided by Alliance of Genome Resources, Apr 2022]

Sox21 Products(1)

mRNA	Protein	Name
NM_177753.3	NP_808421.1	transcription factor SOX-21

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12446692	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12446692	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12446692	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12446692	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within hair cycle	IMP IMP: Inferred from mutant phenotype	19470461	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	19470461	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12446692	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12446692	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	19470461	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor SOX-21

DNA-binding protein SOX21	HMG-box protein SOX21
SRY-box containing gene 21

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13592	SOX21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18684	Sox10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sox21	NCBI	NCBI:11166

Name
Email *

	Sorry, but the email address you supplied was invalid.