Adamts20 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20 Gene

Also Known as bt; Adamst20

Species: Mus musculus

Gene Type: protein coding

Gene ID: 223838

Summary

This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Certain mutations in this gene cause defective development of neural crest-derived melanoblasts resulting in a "belted" phenotype that is characterized by white spots in the lumbar region. [provided by RefSeq, Jul 2016]

Adamts20 Products (3)

mRNA	Protein	Name
NM_001164785.1	NP_001158257.1	A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform 2 precursor
NM_001164786.1	NP_001158258.1	A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform 3 precursor
NM_177431.5	NP_803180.3	A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	18454205	MGI
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	12562771	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	18454205	MGI
acts upstream of or within extracellular matrix organization	IDA IDA: Inferred from direct assay	18454205	MGI
acts upstream of melanocyte differentiation	IGI IGI: Inferred from genetic interaction	18454205	MGI
acts upstream of melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	18454205	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18454205	MGI
acts upstream of or within positive regulation of melanocyte differentiation	IGI IGI: Inferred from genetic interaction	18454205	MGI
acts upstream of or within positive regulation of melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	18454205	MGI
acts upstream of or within positive regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	18454205	MGI
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	12562771	MGI
acts upstream of or within regulation of developmental pigmentation	IGI IGI: Inferred from genetic interaction	18454205	MGI
acts upstream of or within regulation of developmental pigmentation	IMP IMP: Inferred from mutant phenotype	14138974	MGI
acts upstream of signal transduction	IMP IMP: Inferred from mutant phenotype	18454205	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18454205	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
A disintegrin and metalloproteinase with thrombospondin motifs 20

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00302	ADAMTS20 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19289	Adamts20 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25779	Adamts20 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adamts20	NCBI	NCBI:80070