Wnt10b - wingless-type MMTV integration site family, member 10B Gene

Mus musculus

Also known as Wnt12

Gene ID: 22410 | Gene type: protein coding

About Wnt10b

Summary

Predicted to enable cytokine activity and Frizzled binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including animal organ development; positive regulation of cell differentiation; and regulation of transcription, DNA-templated. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including genitourinary system; integumental system; nervous system; surface ectoderm; and tooth. Human ortholog(s) of this gene implicated in obesity; split hand-foot malformation 6; and tooth agenesis. Orthologous to human WNT10B (Wnt family member 10B). [provided by Alliance of Genome Resources, Apr 2022]

Wnt10b Products(1)

mRNA	Protein	Name
NM_011718.2	NP_035848.1	protein Wnt-10b precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G2/M transition of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	19056892	MGI
acts upstream of T cell differentiation	IDA IDA: Inferred from direct assay	19723499	MGI
acts upstream of or within Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	11092808	MGI
acts upstream of anagen	IDA IDA: Inferred from direct assay	18155657	MGI
acts upstream of or within bone trabecula formation	IMP IMP: Inferred from mutant phenotype	15728361	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	10937998	MGI
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	9160667	MGI
acts upstream of or within cellular response to cAMP	IDA IDA: Inferred from direct assay	12055200	MGI
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	19723499	MGI
acts upstream of or within cellular response to parathyroid hormone stimulus	IDA IDA: Inferred from direct assay	19723499	MGI
acts upstream of epithelial cell differentiation	IDA IDA: Inferred from direct assay	18155657	MGI
acts upstream of fat cell differentiation	IDA IDA: Inferred from direct assay	12055200	MGI
acts upstream of or within fungiform papilla development	IMP IMP: Inferred from mutant phenotype	17284610	MGI
acts upstream of hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	9160667	MGI
acts upstream of or within hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	9160667	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	15673614	MGI
acts upstream of or within myoblast development	IMP IMP: Inferred from mutant phenotype	15673614	MGI
acts upstream of or within myoblast differentiation involved in skeletal muscle regeneration	IMP IMP: Inferred from mutant phenotype	15673614	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	15190075	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	18155657	MGI
acts upstream of or within negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	10937998	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15673614	MGI
acts upstream of osteoblast differentiation	IDA IDA: Inferred from direct assay	19723499	MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19056892	MGI
acts upstream of or within positive regulation of G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	19056892	MGI
acts upstream of or within positive regulation of RNA polymerase II transcription preinitiation complex assembly	IDA IDA: Inferred from direct assay	19056892	MGI
acts upstream of or within positive regulation of T cell differentiation	IDA IDA: Inferred from direct assay	19723499	MGI
acts upstream of or within positive regulation of bone mineralization	IDA IDA: Inferred from direct assay	15728361	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	19723499	MGI
acts upstream of or within positive regulation of epithelial cell differentiation	IDA IDA: Inferred from direct assay	18155657	MGI
acts upstream of or within positive regulation of hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	9160667	MGI
acts upstream of or within positive regulation of ossification	IGI IGI: Inferred from genetic interaction	19723499	MGI
acts upstream of or within positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	15728361	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15728361	MGI
acts upstream of or within positive regulation of timing of anagen	IDA IDA: Inferred from direct assay	18155657	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9769173	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17284610	MGI
acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	19056892	MGI
acts upstream of or within regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	15673614	MGI
acts upstream of or within regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19056892	MGI
acts upstream of or within regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19056892	MGI
acts upstream of or within regulation of protein metabolic process	IMP IMP: Inferred from mutant phenotype	15728361	MGI
acts upstream of or within regulation of skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	15673614	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18155657	MGI
acts upstream of or within sensory perception of taste	IMP IMP: Inferred from mutant phenotype	17284610	MGI
acts upstream of or within skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	15673614	MGI
acts upstream of or within skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	15673614	MGI
acts upstream of or within smoothened signaling pathway	IDA IDA: Inferred from direct assay	17284610	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17284610	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein Wnt-10b

wingless related MMTV integration site 10b

wnt-12

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15829	WNT10B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wnt10b	NCBI	NCBI:7480

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