Wnt10b - wingless-type MMTV integration site family, member 10B Gene

Also Known as Wnt12

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22410

Summary

Predicted to enable cytokine activity and Frizzled binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including animal organ development; positive regulation of cell differentiation; and regulation of transcription, DNA-templated. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including genitourinary system; integumental system; nervous system; surface ectoderm; and tooth. Human ortholog(s) of this gene implicated in obesity; split hand-foot malformation 6; and tooth agenesis. Orthologous to human WNT10B (Wnt family member 10B). [provided by Alliance of Genome Resources, Apr 2022]

Wnt10b Products (1)

mRNA Protein Name
NM_011718.2 NP_035848.1 protein Wnt-10b precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within G2/M transition of mitotic cell cycle IGI
IGI: Inferred from genetic interaction
19056892 MGI
acts upstream of T cell differentiation IDA
IDA: Inferred from direct assay
19723499 MGI
acts upstream of or within Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
11092808 MGI
acts upstream of anagen IDA
IDA: Inferred from direct assay
18155657 MGI
acts upstream of or within bone trabecula formation IMP
IMP: Inferred from mutant phenotype
15728361 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
10937998 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
9160667 MGI
acts upstream of or within cellular response to cAMP IDA
IDA: Inferred from direct assay
12055200 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19723499 MGI
acts upstream of or within cellular response to parathyroid hormone stimulus IDA
IDA: Inferred from direct assay
19723499 MGI
acts upstream of epithelial cell differentiation IDA
IDA: Inferred from direct assay
18155657 MGI
acts upstream of fat cell differentiation IDA
IDA: Inferred from direct assay
12055200 MGI
acts upstream of or within fungiform papilla development IMP
IMP: Inferred from mutant phenotype
17284610 MGI
acts upstream of hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
9160667 MGI
acts upstream of or within hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
9160667 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
15673614 MGI
acts upstream of or within myoblast development IMP
IMP: Inferred from mutant phenotype
15673614 MGI
acts upstream of or within myoblast differentiation involved in skeletal muscle regeneration IMP
IMP: Inferred from mutant phenotype
15673614 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
15190075 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
18155657 MGI
acts upstream of or within negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
10937998 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15673614 MGI
acts upstream of osteoblast differentiation IDA
IDA: Inferred from direct assay
19723499 MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
19056892 MGI
acts upstream of or within positive regulation of G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
19056892 MGI
acts upstream of or within positive regulation of RNA polymerase II transcription preinitiation complex assembly IDA
IDA: Inferred from direct assay
19056892 MGI
acts upstream of or within positive regulation of T cell differentiation IDA
IDA: Inferred from direct assay
19723499 MGI
acts upstream of or within positive regulation of bone mineralization IDA
IDA: Inferred from direct assay
15728361 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
19723499 MGI
acts upstream of or within positive regulation of epithelial cell differentiation IDA
IDA: Inferred from direct assay
18155657 MGI
acts upstream of or within positive regulation of hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
9160667 MGI
acts upstream of or within positive regulation of ossification IGI
IGI: Inferred from genetic interaction
19723499 MGI
acts upstream of or within positive regulation of ossification IMP
IMP: Inferred from mutant phenotype
15728361 MGI
acts upstream of or within positive regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
15728361 MGI
acts upstream of or within positive regulation of timing of anagen IDA
IDA: Inferred from direct assay
18155657 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9769173 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17284610 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
19056892 MGI
acts upstream of or within regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
15673614 MGI
acts upstream of or within regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19056892 MGI
acts upstream of or within regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
19056892 MGI
acts upstream of or within regulation of protein metabolic process IMP
IMP: Inferred from mutant phenotype
15728361 MGI
acts upstream of or within regulation of skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
15673614 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18155657 MGI
acts upstream of or within sensory perception of taste IMP
IMP: Inferred from mutant phenotype
17284610 MGI
acts upstream of or within skeletal muscle fiber development IMP
IMP: Inferred from mutant phenotype
15673614 MGI
acts upstream of or within skeletal muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
15673614 MGI
acts upstream of or within smoothened signaling pathway IDA
IDA: Inferred from direct assay
17284610 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17284610 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Wnt-10b

  • wingless related MMTV integration site 10b

  • wnt-12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15829 WNT10B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnt10b NCBI NCBI:7480