WNT10B - Wnt family member 10B Gene

Also Known as SHFM6; STHAG8; WNT-12

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7480

About WNT10B

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:48,965,340-48,971,735 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues, 18 paralogues and is associated with 5 phenotypes. Broad expression in brain (RPKM 3.0), skin (RPKM 0.8) and 15 other tissues.

Summary

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family. It may be involved in breast Cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, Wnt1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

WNT10B Products (1)

mRNA	Protein	Name
NM_003394.4	NP_003385.2	protein Wnt-10b precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17761539	GOA
involved in chondrocyte differentiation	IEP IEP: Inferred from expression pattern	15135146	GOA
involved in hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	9787155	GOA
involved in negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	10937998	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17761539	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	10937998	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT10B Protein Structure

wnt

0
100
200
300
389 a.a.

Protein Preferred Names	Protein Names
protein Wnt-10b	WNT-10B protein

WNT10B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WNT10B	O00744	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	WNT10B	O00744	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	WNT10B	O00744	APP	Homo sapiens	P05067	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

WNT10B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83798	Wnt-10b Antibody (YA3495)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P83798A	Wnt-10b Antibody (YA3495)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human
HY-P85410	Wnt-10b Antibody (YA5102)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue	Human, Rat

Related Diseases

Diseases	Alias
Split-Hand/Foot Malformation 6	Split Hand-Foot Malformation 6 SHFM6 Ectrodactyly, Autosomal Recessive Ectrodactyly Autosomal Recessive Split-Hand/Foot Malformation, Type 6
Tooth Agenesis, Selective, 8	STHAG8 Selective Tooth Agenesis 8
Isolated Split Hand-Split Foot Malformation	Ectrodactyly Shfm Split Hand Foot Malformation Split-Hand/Foot Malformation Split Hand Foot Deformity 1 Split Hand Foot Deformity
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Split Hand-Foot Malformation	Ectrodactyly Split-Hand/Foot Malformation Lobster-Claw Deformity Split-Hand Deformity Split Hand Foot Malformation Shfm Split Hand Foot Deformity Split Hand Foot Deformity 1
Fibular Aplasia Or Hypoplasia, Femoral Bowing And Poly-, Syn-, And Oligodactyly	Fuhrmann Syndrome Bowing Of The Femurs, Aplasia Or Hypoplasia Of The Fibula, And Digital Anomalies Fibular Hypoplasia Or Aplasia-Femoral Bowing-Oligodactyly Syndrome Fuhrmann-Rieger-De Sousa Syndrome FUHRS Fibular Aplasia Hypoplasia Femoral Bowing And Poly- Syn- And Oligodactyly
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Split-Hand/Foot Malformation 4	SHFM4 Split Hand-Foot Malformation 4 Split-Hand/Foot Malformation, Type 4
Split-Hand/Foot Malformation 2	SHFM2 Shfd2 Shsf2 Split Hand/Foot Malformation 2 Split Hand-Foot Malformation 2 Split-Hand/Split-Foot Anomaly, X-Linked Split-Hand/Foot Deformity 2 Split Hand/Foot Malformation X-Linked Split Hand Foot Anomaly - X-Linked Split Hand Foot Deformity 2
Orofacial Cleft 4	OFC4 Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 4 Nonsyndromic Cleft Lip With Or Without Cleft Palate 4
Split-Hand/Foot Malformation 3	SHFM3 Split Hand-Foot Malformation 3 Chromosome 10q24 Duplication Syndrome Shsf3 Limb Deficiencies, Distal, With Micrognathia Split-Hand/Foot Malformation 3, Gene Duplication Syndrome Distal Limb Deficiencies With Micrognathia Limb Deficiencies Distal With Micrognathia Buttiens Fryns Syndrome Distal Limb Deficiencies-Micrognathia Syndrome 10q24 Microduplication Syndrome Buttiens-Fryns Syndrome Split-Hand/Foot Malformation, Type 3, Gene Duplication Syndrome
Tetraamelia Syndrome	Tetra-Amelia Syndrome Tetraamelia-Multiple Malformations Syndrome Tetra-Amelia Tetra-Amelia, Autosomal Recessive Tetraamelia, Autosomal Recessive Total Amelia Zimmer Phocomelia Tetams Zimmer Taub Sova Syndrome
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Osteoporosis-Pseudoglioma Syndrome	OPPG Ops Osteoporosis With Pseudoglioma Osteogenesis Imperfecta, Ocular Form Ocular Form Of Osteogenesis Imperfecta Osteogenesis Imperfecta Ocular Form Osteoporosis Pseudoglioma Syndrome Pseudoglioma With Bone Fragility
Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss, Autosomal Recessive	Split Hand-Foot Malformation 1 With Sensorineural Hearing Loss SHFM1D Deafness, Congenital, With Split Hands And Feet Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss Congenital Deafness With Split Hands And Feet Split Hand-Split Foot-Deafness Syndrome Split Hand-Split Foot-Hearing Loss Syndrome Congenital Deafness And Split Hands And Feet Split-Hand/Foot Malformation, Type 1 With Sensorineural Hearing Loss Split-Hand-Foot Malformation With Sensorineural Hearing Loss
Endosteal Hyperostosis, Autosomal Dominant	Osteosclerosis Worth Syndrome Osteosclerosis, Autosomal Dominant Hyperostosis, Endosteal Endosteal Hyperostosis, Worth Type Worth Disease Autosomal Dominant Endosteal Hyperostosis Autosomal Dominant Osteosclerosis, Worth Type Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus Autosomal Dominant Osteosclerosis Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus Worth'S Syndrome Worth Type Autosomal Dominant Osteosclerosis Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus Osteosclerosis, Autosomal Dominant, Worth Type WENHY Endosteal Hyperostosis Autosomal Dominant Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus Osteosclerosis Autosomal Dominant Acquired Osteosclerosis
Androgenic Alopecia	Androgenetic Alopecia Alopecia Androgenetica, Male Pattern Baldness
Van Buchem Disease	Hyperostosis Corticalis Generalisata Hyperphosphatasemia Tarda VBCH Sost-Related Sclerosing Bone Dysplasia Endosteal Hyperostosis Autosomal Recessive Sclerosteosis Endosteal Hyperostosis, Autosomal Recessive Hyperotosis Corticalis Generalisata Familiaris Sost Sclerosing Bone Dysplasia Smith-Lemli-Opitz Syndrome
Ectodermal Dysplasia 13, Hair/Tooth Type	ECTD13 Ectodermal Dysplasia 13
Ulna And Fibula, Absence Of, With Severe Limb Deficiency	Schinzel Phocomelia Syndrome Aarrs Limb/Pelvis-Hypoplasia/Aplasia Syndrome LPHAS Schinzel Type Phocomelia Absence Of Ulna And Fibula With Severe Limb Deficiency Al-Awadi/Raas-Rothschild Syndrome Al Awadi-Raas-Rothschild Syndrome Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome Aplasia/Hypoplasia Of Limbs And Pelvis Congenital Absence Of Ulna And Fibula Severe Limb Deficit Phocomelia, Schinzel Type Al-Awadi-Raas-Rothschild Syndrome Ulna And Fibula Absence Of With Severe Limb Deficiency Limb Pelvis Hypoplasia Aplasia Syndrome Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome Ulna And Fibula, Absence Of, With Sever Limb Deficiency
Sclerosteosis	Cortical Hyperostosis With Syndactyly Sost Cortical Hyperostosis-Syndactyly Syndrome
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive	Hypohidrotic Ectodermal Dysplasia Hed Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic Eda Christ-Siemens-Touraine Syndrome ECTD10B Ectodermal Dysplasia Anhidrotic Ectodermal Dysplasia, Anhidrotic Cst Syndrome Ectodermal Dysplasia Hypohidrotic Autosomal Recessive Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive Dysplasia, Ectodermal, Hypohidrotic Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive Ectodermal Dysplasia 3, Anhidrotic Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15829	WNT10B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WNT10B	MGD	MGI:108061
Felis catus	WNT10B	VGNC	VGNC:67081
Bos taurus	WNT10B	VGNC	VGNC:56232
Macaca mulatta	WNT10B	VGNC	VGNC:100119
Rattus norvegicus	WNT10B	RGD	RGD:1304988
Others	WNT10B	NCBI