Wnt2 - wingless-type MMTV integration site family, member 2 Gene

Also Known as Irp; Mirp; Wnt-2; Wnt2a; Int1l1; 2610510E18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22413

Summary

Predicted to enable cytokine activity and Frizzled binding activity. Involved in cell proliferation in midbrain and positive regulation of neurogenesis. Acts upstream of or within several processes, including circulatory system development; lung induction; and positive regulation of cell population proliferation. Predicted to be located in collagen-containing extracellular matrix and cytoplasm. Predicted to be extrinsic component of external side of plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including embryo mesenchyme; face; heart and pericardium; reproductive system; and urethra. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system Cancer. Orthologous to human Wnt2 (Wnt family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Wnt2 Products (1)

mRNA Protein Name
NM_023653.5 NP_076142.3 protein Wnt-2 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
11092808 MGI
acts upstream of or within atrial cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
20159597 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
9652750 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19686689 MGI
acts upstream of or within canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20159597 MGI
acts upstream of or within cardiac epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
20159597 MGI
acts upstream of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
20159597 MGI
involved in cell proliferation in midbrain IMP
IMP: Inferred from mutant phenotype
20018874 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19686689 MGI
acts upstream of epithelial cell proliferation involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
19686689 MGI
acts upstream of or within labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
8951051 MGI
acts upstream of or within lung induction IGI
IGI: Inferred from genetic interaction
19686689 MGI
acts upstream of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
19686689 MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
20159597 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19686689 MGI
acts upstream of or within positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
19686689 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
19686689 MGI
involved in positive regulation of neurogenesis IDA
IDA: Inferred from direct assay
20018874 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20159597 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Wnt-2

  • INT-1-related protein

  • wingless-related MMTV integration site 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183400 BIM-46174 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnt2 NCBI NCBI:7472