Wnt4 - wingless-type MMTV integration site family, member 4 Gene

Also Known as Wnt-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22417

Summary

Enables Frizzled binding activity and transcription corepressor activity. Involved in several processes, including paramesonephric duct development; positive regulation of cellular component biogenesis; and regulation of cellular biosynthetic process. Acts upstream of or within several processes, including animal organ development; negative regulation of signal transduction; and renal vesicle induction. Located in cell surface; extracellular matrix; and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Wnt4 Products (1)

mRNA Protein Name
NM_009523.2 NP_033549.1 protein Wnt-4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables frizzled binding IPI
IPI: Inferred from physical interaction
15265686 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9853965 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
12949260 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Sertoli cell differentiation IMP
IMP: Inferred from mutant phenotype
15581876 MGI
acts upstream of or within T cell differentiation in thymus IDA
IDA: Inferred from direct assay
11265645 MGI
acts upstream of or within anatomical structure development IGI
IGI: Inferred from genetic interaction
16818445 MGI
acts upstream of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
20454446 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
16054034 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IGI
IGI: Inferred from genetic interaction
11948913 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
11265645 MGI
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
15265686 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
20454446 MGI
acts upstream of cell differentiation IMP
IMP: Inferred from mutant phenotype
15581876 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
18351662 MGI
acts upstream of or within cellular response to starvation IEP
IEP: Inferred from expression pattern
23260145 MGI
acts upstream of or within embryonic epithelial tube formation IDA
IDA: Inferred from direct assay
16546160 MGI
acts upstream of or within female gonad development IMP
IMP: Inferred from mutant phenotype
15162500 MGI
acts upstream of fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
16700629 MGI
acts upstream of or within gamete generation IGI
IGI: Inferred from genetic interaction
15162500 MGI
acts upstream of or within hormone metabolic process IMP
IMP: Inferred from mutant phenotype
12399432 MGI
acts upstream of or within immature T cell proliferation in thymus IMP
IMP: Inferred from mutant phenotype
18617424 MGI
acts upstream of or within kidney morphogenesis IGI
IGI: Inferred from genetic interaction
23362348 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
15581876 MGI
acts upstream of meiotic nuclear division IGI
IGI: Inferred from genetic interaction
20106871 MGI
acts upstream of or within mesenchymal to epithelial transition IMP
IMP: Inferred from mutant phenotype
7990960 MGI
acts upstream of or within mesonephric tubule development IGI
IGI: Inferred from genetic interaction
20040500 MGI
involved in mesonephros development IMP
IMP: Inferred from mutant phenotype
14695376 MGI
acts upstream of or within metanephric nephron development IMP
IMP: Inferred from mutant phenotype
18346943 MGI
acts upstream of or within metanephric nephron morphogenesis IMP
IMP: Inferred from mutant phenotype
19830824 MGI
acts upstream of or within metanephric tubule formation IMP
IMP: Inferred from mutant phenotype
21350016 MGI
acts upstream of or within metanephros development IMP
IMP: Inferred from mutant phenotype
7990960 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12949260 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19301398 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
20454446 MGI
acts upstream of or within negative regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
15581876 MGI
involved in negative regulation of cell migration IGI
IGI: Inferred from genetic interaction
23027131 MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
16700629 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
11948913 MGI
involved in negative regulation of testosterone biosynthetic process IMP
IMP: Inferred from mutant phenotype
12949260 MGI
involved in negative regulation of wound healing IGI
IGI: Inferred from genetic interaction
23027131 MGI
acts upstream of or within nephron development IMP
IMP: Inferred from mutant phenotype
21295565 MGI
acts upstream of or within non-canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
18617424 MGI
acts upstream of or within oocyte development IGI
IGI: Inferred from genetic interaction
20454446 MGI
acts upstream of or within oocyte development IMP
IMP: Inferred from mutant phenotype
9989404 MGI
acts upstream of or within paramesonephric duct development IMP
IMP: Inferred from mutant phenotype
19830824 MGI
involved in paramesonephric duct development IMP
IMP: Inferred from mutant phenotype
14695376 MGI
acts upstream of or within pericyte cell differentiation IDA
IDA: Inferred from direct assay
16546160 MGI
acts upstream of or within pericyte cell differentiation IMP
IMP: Inferred from mutant phenotype
16546160 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9356179 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11283799 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19301398 MGI
involved in positive regulation of GTPase activity IGI
IGI: Inferred from genetic interaction
23027131 MGI
involved in positive regulation of focal adhesion assembly IGI
IGI: Inferred from genetic interaction
23027131 MGI
acts upstream of or within positive regulation of meiotic nuclear division IGI
IGI: Inferred from genetic interaction
20106871 MGI
involved in positive regulation of stress fiber assembly IGI
IGI: Inferred from genetic interaction
23027131 MGI
acts upstream of or within regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
20106871 MGI
acts upstream of or within renal vesicle formation IMP
IMP: Inferred from mutant phenotype
16054034 MGI
acts upstream of or within renal vesicle induction IDA
IDA: Inferred from direct assay
11507767 MGI
acts upstream of or within sex differentiation IMP
IMP: Inferred from mutant phenotype
9989404 MGI
acts upstream of or within smooth muscle cell differentiation IDA
IDA: Inferred from direct assay
16546160 MGI
acts upstream of or within smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
16546160 MGI
acts upstream of or within somatotropin secreting cell differentiation IMP
IMP: Inferred from mutant phenotype
18351662 MGI
acts upstream of or within tertiary branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
10733525 MGI
acts upstream of or within thyroid-stimulating hormone-secreting cell differentiation IMP
IMP: Inferred from mutant phenotype
18351662 MGI
acts upstream of or within tube morphogenesis IMP
IMP: Inferred from mutant phenotype
16546160 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
8167409 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
8167409 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
23027131 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Wnt-4

  • signal molecule

  • wingless-related MMTV integration site 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15836 WNT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17196 Wnt4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23648 Wnt4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnt4 NCBI NCBI:54361