Setd4 - SET domain containing 4 Gene

Also Known as ORF21; C21orf18

Species: Mus musculus

Gene Type: protein coding
Gene ID: 224440

Summary

Enables Histone Methyltransferase activity (H3-K4 specific). Involved in several processes, including histone H3-K4 methylation; positive regulation of cytokine production; and regulation of cell proliferation in bone marrow. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human SETD4 (SET domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]

Setd4 Products (1)

mRNA Protein Name
NM_145482.3 NP_663457.2 SET domain-containing protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables histone H3K4 methyltransferase activity IDA
IDA: Inferred from direct assay
31376731 MGI
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
31376731 MGI
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
31376731 MGI
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
31376731 MGI
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
31376731 MGI
involved in regulation of cell proliferation in bone marrow IMP
IMP: Inferred from mutant phenotype
33506343 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SET domain-containing protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12744 SETD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Setd4 NCBI NCBI:54093