SETD4 - SET domain containing 4 Gene

Also Known as C21orf18; C21orf27

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54093

About SETD4

This gene has 17 transcripts (splice variants), 197 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 7.1), skin (RPKM 4.7) and 25 other tissues.

Summary

Enables Histone Methyltransferase activity (H4-K20 specific). Involved in histone H4-K20 trimethylation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SETD4 Products (4)

mRNA Protein Name
NM_001007259.3 NP_001007260.1 SET domain-containing protein 4 isoform 2
NM_001007261.3 NP_001007262.1 SET domain-containing protein 4 isoform 4
NM_001286752.2 NP_001273681.1 SET domain-containing protein 4 isoform 3
NM_017438.5 NP_059134.1 SET domain-containing protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H4K20 methyltransferase activity IDA
IDA: Inferred from direct assay
31308046 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
24738023 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24738023 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SETD4 Protein Structure

SET

SET: SET domain (59 - 273)

Rubis-subs-bind

Rubis-subs-bind: Rubisco LSMT substrate-binding (307 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

SET domain-containing protein 4

Related Diseases

Diseases Alias
Thymus Lymphoma

  • Thymic Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12744 SETD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SETD4 RGD RGD:619899
Bos taurus SETD4 VGNC VGNC:34495
Macaca mulatta SETD4 VGNC VGNC:77224
Felis catus SETD4 VGNC VGNC:65043
Canis familiaris SETD4 VGNC VGNC:46056
Mus musculus SETD4 MGD MGI:2136890
Others SETD4 NCBI