Lemd2 - LEM domain containing 2 Gene

Also Known as Lem2; NET25

Species: Mus musculus

Gene Type: protein coding
Gene ID: 224640

Summary

Predicted to enable chromatin DNA binding activity. Involved in heart formation; negative regulation of protein kinase B signaling; and neurogenesis. Acts upstream of or within negative regulation of MAPK cascade and skeletal muscle cell differentiation. Located in nuclear membrane. Is expressed in several structures, including heart; liver; nephric duct; neural tube; and tibialis anterior. Human ortholog(s) of this gene implicated in cataract 46 juvenile-onset. Orthologous to human LEMD2 (LEM domain nuclear envelope protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lemd2 Products (1)

mRNA Protein Name
NM_146075.2 NP_666187.2 LEM domain-containing protein 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in heart formation IMP
IMP: Inferred from mutant phenotype
25790465 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
19720741 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
25790465 MGI
involved in neurogenesis IMP
IMP: Inferred from mutant phenotype
25790465 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
19720741 MGI
Cellular Component GO Annotation Evidence References Source
located in nuclear membrane IDA
IDA: Inferred from direct assay
16339967 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

LEM domain-containing protein 2

  • nuclear envelope constituent

  • nuclear envelope transmembrane protein 25

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07588 LEMD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lemd2 NCBI NCBI:221496