2. Gene
  3. Lemd2 - LEM domain containing 2 Gene

Lemd2 - LEM domain containing 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Lem2; NET25

Gene ID: 224640 | Gene type: protein coding

About Lemd2

Summary

Predicted to enable chromatin DNA binding activity. Involved in heart formation; negative regulation of protein kinase B signaling; and neurogenesis. Acts upstream of or within negative regulation of MAPK cascade and skeletal muscle cell differentiation. Located in nuclear membrane. Is expressed in several structures, including heart; liver; nephric duct; neural tube; and tibialis anterior. Human ortholog(s) of this gene implicated in cataract 46 juvenile-onset. Orthologous to human LEMD2 (LEM domain nuclear envelope protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lemd2 Products(1)

mRNA Protein Name
NM_146075.2 NP_666187.2 LEM domain-containing protein 2
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in heart formation IMP
IMP: Inferred from mutant phenotype
25790465 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
19720741 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
25790465 MGI
involved in neurogenesis IMP
IMP: Inferred from mutant phenotype
25790465 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
19720741 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nuclear membrane IDA
IDA: Inferred from direct assay
16339967 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

LEM domain-containing protein 2

nuclear envelope constituent

nuclear envelope transmembrane protein 25

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07588 LEMD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lemd2 NCBI NCBI:221496