Bag6 - BCL2-associated athanogene 6 Gene

Also Known as G3; Bat3; BAG-6; Scythe; D17H6S52E; 2410045D21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 224727

Summary

Enables HSP70 protein binding activity; polyubiquitin modification-dependent protein binding activity; and Proteasome binding activity. Involved in several processes, including animal organ development; protein stabilization; and synaptonemal complex assembly. Acts upstream of or within negative regulation of apoptotic process. Located in cytosol and nucleus. Is expressed in palatal shelf epithelium. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human BAG6 (BAG cochaperone 6). [provided by Alliance of Genome Resources, Apr 2022]

Bag6 Products (38)

mRNA Protein Name
NM_001252468.2 NP_001239397.1 large proline-rich protein BAG6 isoform 2
NM_001252469.2 NP_001239398.1 large proline-rich protein BAG6 isoform 3
NM_001372260.1 NP_001359189.1 large proline-rich protein BAG6 isoform 4
NM_001372261.1 NP_001359190.1 large proline-rich protein BAG6 isoform 5
NM_001372262.1 NP_001359191.1 large proline-rich protein BAG6 isoform 6
NM_001372265.1 NP_001359194.1 large proline-rich protein BAG6 isoform 7
NM_001372266.1 NP_001359195.1 large proline-rich protein BAG6 isoform 12
NM_001372267.1 NP_001359196.1 large proline-rich protein BAG6 isoform 1
NM_001372268.1 NP_001359197.1 large proline-rich protein BAG6 isoform 1
NM_001372269.1 NP_001359198.1 large proline-rich protein BAG6 isoform 2
NM_001372270.1 NP_001359199.1 large proline-rich protein BAG6 isoform 2
NM_001372271.1 NP_001359200.1 large proline-rich protein BAG6 isoform 2
NM_001372272.1 NP_001359201.1 large proline-rich protein BAG6 isoform 2
NM_001372273.1 NP_001359202.1 large proline-rich protein BAG6 isoform 8
NM_001372274.1 NP_001359203.1 large proline-rich protein BAG6 isoform 8
NM_001372275.1 NP_001359204.1 large proline-rich protein BAG6 isoform 9
NM_001372276.1 NP_001359205.1 large proline-rich protein BAG6 isoform 10
NM_001372277.1 NP_001359206.1 large proline-rich protein BAG6 isoform 10
NM_001372278.1 NP_001359207.1 large proline-rich protein BAG6 isoform 10
NM_001372279.1 NP_001359208.1 large proline-rich protein BAG6 isoform 2
NM_001372280.1 NP_001359209.1 large proline-rich protein BAG6 isoform 11
NM_001372281.1 NP_001359210.1 large proline-rich protein BAG6 isoform 11
NM_001372282.1 NP_001359211.1 large proline-rich protein BAG6 isoform 11
NM_001372283.1 NP_001359212.1 large proline-rich protein BAG6 isoform 3
NM_001372284.1 NP_001359213.1 large proline-rich protein BAG6 isoform 12
NM_001372285.1 NP_001359214.1 large proline-rich protein BAG6 isoform 12
NM_001372286.1 NP_001359215.1 large proline-rich protein BAG6 isoform 13
NM_001372287.1 NP_001359216.1 large proline-rich protein BAG6 isoform 13
NM_001372288.1 NP_001359217.1 large proline-rich protein BAG6 isoform 14
NM_001372289.1 NP_001359218.1 large proline-rich protein BAG6 isoform 15
NM_001372290.1 NP_001359219.1 large proline-rich protein BAG6 isoform 15
NM_001372291.1 NP_001359220.1 large proline-rich protein BAG6 isoform 16
NM_001404327.1 NP_001391256.1 large proline-rich protein BAG6 isoform 4
NM_001404328.1 NP_001391257.1 large proline-rich protein BAG6 isoform 5
NM_001404329.1 NP_001391258.1 large proline-rich protein BAG6 isoform 5
NM_001404330.1 NP_001391259.1 large proline-rich protein BAG6 isoform 17
NM_001404331.1 NP_001391260.1 large proline-rich protein BAG6 isoform 9
NM_057171.3 NP_476512.1 large proline-rich protein BAG6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp70 protein binding IPI
IPI: Inferred from physical interaction
18678708 MGI
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
20713601 MGI
enables proteasome binding IDA
IDA: Inferred from direct assay
20713601 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
Biological Process GO Annotation Evidence References Source
involved in brain development IMP
IMP: Inferred from mutant phenotype
16287848 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
18056262 MGI
involved in kidney development IMP
IMP: Inferred from mutant phenotype
16287848 MGI
involved in lung development IMP
IMP: Inferred from mutant phenotype
16287848 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
21460186 MGI
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
18678708 MGI
involved in negative regulation of proteolysis IMP
IMP: Inferred from mutant phenotype
18056262 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
26692333 MGI
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
18056262 MGI
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16287848 MGI
involved in regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
16287848 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
18678708 MGI
involved in synaptonemal complex assembly IMP
IMP: Inferred from mutant phenotype
18678708 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
20713601 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
18056262 MGI
located in nucleus IDA
IDA: Inferred from direct assay
21460186 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

large proline-rich protein BAG6

  • BAG family molecular chaperone regulator 6

  • HLA-B-associated transcript 3

  • large proline-rich protein BAT3

  • protein Scythe

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01347 BAG6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bag6 NCBI NCBI:7917