Lims2 - LIM and senescent cell antigen like domains 2 Gene

Also Known as PINCH2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 225341

Summary

Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including cell-cell junction organization; negative regulation of cell population proliferation; and positive regulation of integrin-mediated signaling pathway. Located in focal adhesion. Is expressed in several structures, including early conceptus; lower urinary tract; nervous system; and oocyte. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Orthologous to human LIMS2 (LIM zinc finger domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Lims2 Products (4)

mRNA Protein Name
NM_001365015.1 NP_001351944.1 LIM and senescent cell antigen-like-containing domain protein 2 isoform 2
NM_001379137.1 NP_001366066.1 LIM and senescent cell antigen-like-containing domain protein 2 isoform 1
NM_001379138.1 NP_001366067.1 LIM and senescent cell antigen-like-containing domain protein 2 isoform 2
NM_144862.4 NP_659111.1 LIM and senescent cell antigen-like-containing domain protein 2 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell-cell adhesion IGI
IGI: Inferred from genetic interaction
19652092 MGI
acts upstream of or within cell-cell junction organization IGI
IGI: Inferred from genetic interaction
19652092 MGI
acts upstream of cholangiocyte proliferation IGI
IGI: Inferred from genetic interaction
24058607 MGI
acts upstream of integrin-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
19652092 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
24058607 MGI
acts upstream of or within negative regulation of cholangiocyte proliferation IGI
IGI: Inferred from genetic interaction
24058607 MGI
acts upstream of or within negative regulation of hepatocyte proliferation IGI
IGI: Inferred from genetic interaction
24058607 MGI
acts upstream of or within negative regulation of neural precursor cell proliferation IGI
IGI: Inferred from genetic interaction
24719101 MGI
acts upstream of neural precursor cell proliferation IGI
IGI: Inferred from genetic interaction
24719101 MGI
acts upstream of or within positive regulation of integrin-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
19652092 MGI
Cellular Component GO Annotation Evidence References Source
located in focal adhesion IDA
IDA: Inferred from direct assay
12651156 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

LIM and senescent cell antigen-like-containing domain protein 2

  • particularly interesting new Cys-His protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07656 LIM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07669 LIMS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lims2 NCBI NCBI:55679