Ticam2 - toll-like receptor adaptor molecule 2 Gene

Also Known as TRAM; Tirp; Trif; TICAM-2; B430113A10

Species: Mus musculus

Gene Type: protein coding
Gene ID: 225471

Summary

Enables phospholipid binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of interleukin-18-mediated signaling pathway; and response to interleukin-12. Acts upstream of or within defense response to virus and regulation of cytokine production. Located in endosome and plasma membrane. Is expressed in testis and ureter. Used to study Coronavirus infectious disease. Orthologous to several human genes including TMED7-TICAM2 (TMED7-TICAM2 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Ticam2 Products (1)

mRNA Protein Name
NM_173394.3 NP_775570.1 TIR domain-containing adapter molecule 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phospholipid binding IDA
IDA: Inferred from direct assay
18297073 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14517278 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within defense response to virus IMP
IMP: Inferred from mutant phenotype
25268627 MGI
involved in phagocytosis IMP
IMP: Inferred from mutant phenotype
30883606 MGI
involved in positive regulation of chemokine (C-C motif) ligand 5 production IDA
IDA: Inferred from direct assay
18297073 MGI
involved in positive regulation of interleukin-18-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22685567 MGI
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
18297073 MGI
involved in positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
22685567 MGI
acts upstream of or within regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
14556004 MGI
involved in response to interleukin-12 IMP
IMP: Inferred from mutant phenotype
22685567 MGI
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
18297073 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18297073 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TIR domain-containing adapter molecule 2

  • TIR domain-containing adapter protein

  • TRIF-related adapter molecule TRAM

  • TRIF-related adaptor molecule

  • Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2

  • toll/interleukin-1 receptor domain-containing protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14518 TICAM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ticam2 NCBI NCBI:353376