2. Gene
  3. Cep120 - centrosomal protein 120 Gene

Cep120 - centrosomal protein 120 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ccdc100; A230075C01

Gene ID: 225523 | Gene type: protein coding

About Cep120

Summary

Enables protein C-terminus binding activity. Involved in centrosome cycle; positive regulation of centrosome duplication; and positive regulation of cilium assembly. Acts upstream of or within several processes, including astral microtubule organization; nervous system development; and regulation of microtubule-based process. Located in centriole and centrosome. Is expressed in nervous system and sensory organ. Human ortholog(s) of this gene implicated in Joubert syndrome 31 and short-rib thoracic dysplasia 13 with or without polydactyly. Orthologous to human CEP120 (centrosomal protein 120). [provided by Alliance of Genome Resources, Apr 2022]

Cep120 Products(1)

mRNA Protein Name
NM_178686.4 NP_848801.2 centrosomal protein of 120 kDa
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17920017 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within astral microtubule organization IDA
IDA: Inferred from direct assay
17920017 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
17920017 MGI
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
25251415 MGI
acts upstream of or within cerebral cortex development IMP
IMP: Inferred from mutant phenotype
17920017 MGI
acts upstream of or within interkinetic nuclear migration IMP
IMP: Inferred from mutant phenotype
17920017 MGI
acts upstream of or within microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
17920017 MGI
acts upstream of or within neurogenesis IMP
IMP: Inferred from mutant phenotype
17875675 MGI
involved in positive regulation of centrosome duplication IMP
IMP: Inferred from mutant phenotype
25251415 MGI
involved in positive regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
25251415 MGI
acts upstream of or within regulation of microtubule-based process IMP
IMP: Inferred from mutant phenotype
17920017 MGI
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
17920017 MGI
Cellular Component GO Annotation Evidence Reference Source
located in centriole IDA
IDA: Inferred from direct assay
25251415 MGI
located in centrosome IDA
IDA: Inferred from direct assay
17920017 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

centrosomal protein of 120 kDa

coiled-coil domain-containing protein 100

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112500 Spindlactone B Inhibitor / Unkown
HY-RS02498 CEP120 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cep120 NCBI NCBI:153241