2. Gene
  3. Sh3tc2 - SH3 domain and tetratricopeptide repeats 2 Gene

Sh3tc2 - SH3 domain and tetratricopeptide repeats 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as D430044G18Rik

Gene ID: 225608 | Gene type: protein coding

About Sh3tc2

Summary

Acts upstream of or within peripheral nervous system myelin maintenance; regulation of ERBB signaling pathway; and regulation of intracellular protein transport. Located in plasma membrane and recycling endosome. Is expressed in several structures, including brain; genitourinary system; submandibular gland; thymus; and trachea. Used to study Charcot-Marie-Tooth disease type 4C. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4C. Orthologous to human SH3TC2 (SH3 domain and tetratricopeptide repeats 2). [provided by Alliance of Genome Resources, Apr 2022]

Sh3tc2 Products(1)

mRNA Protein Name
NM_172628.2 NP_766216.2 SH3 domain and tetratricopeptide repeat-containing protein 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23553667 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within myelination in peripheral nervous system IMP
IMP: Inferred from mutant phenotype
23553667 MGI
acts upstream of or within peripheral nervous system myelin maintenance IMP
IMP: Inferred from mutant phenotype
19805030 MGI
acts upstream of or within regulation of ERBB signaling pathway IMP
IMP: Inferred from mutant phenotype
23553667 MGI
acts upstream of or within regulation of intracellular protein transport IMP
IMP: Inferred from mutant phenotype
23553667 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
23553667 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
23553667 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH3 domain and tetratricopeptide repeat-containing protein 2

SH3 domain and tetratricopeptide repeats-containing protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12848 SH3TC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh3tc2 NCBI NCBI:79628