Catsper1 - cation channel, sperm associated 1 Gene

Mus musculus

Also known as KSper; Catsper

Gene ID: 225865 | Gene type: protein coding

About Catsper1

Summary

Enables voltage-gated Calcium Channel activity. Acts upstream of or within several processes, including flagellated sperm motility; fusion of sperm to egg plasma membrane involved in single fertilization; and regulation of cilium beat frequency involved in ciliary motility. Located in plasma membrane. Part of CatSper complex. Is expressed in germ cell of testis; spermatid; spermatocyte; spermatozoon; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 7. Orthologous to human CATSPER1 (cation channel sperm associated 1). [provided by Alliance of Genome Resources, Apr 2022]

Catsper1 Products(1)

mRNA	Protein	Name
NM_139301.3	NP_647462.1	cation channel sperm-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17227845	MGI
enables voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	17478420	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	11595941	MGI
acts upstream of or within flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	11595941	MGI
acts upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization	IMP IMP: Inferred from mutant phenotype	11595941	MGI
acts upstream of or within regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	14657352	MGI
acts upstream of or within regulation of cilium beat frequency involved in ciliary motility	IMP IMP: Inferred from mutant phenotype	14657352	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	17478420	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of CatSper complex	IDA IDA: Inferred from direct assay	21224844	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11595941	MGI
located in sperm principal piece	IDA IDA: Inferred from direct assay	34225353	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cation channel sperm-associated protein 1

sperm calcium channel 1	sperm ion channel
sperm protein CATSPER1

Catsper1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Catsper1	Q91ZR5	Catsper3	Mus musculus	Q80W99	Anti Bait CoIP	17227845
Intra	Catsper1	Q91ZR5	Catsper3	Mus musculus	Q80W99	Anti Tag CoIP	17227845
Intra	Catsper1	Q91ZR5	Catsper4	Mus musculus	Q8BVN3	Anti Bait CoIP	17227845
Intra	Catsper1	Q91ZR5	Catsper4	Mus musculus	Q8BVN3	Anti Tag CoIP	17227845

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01984	CATSPER1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Catsper1	NCBI	NCBI:117144

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