Catsper1 - cation channel, sperm associated 1 Gene

Also Known as KSper; Catsper

Species: Mus musculus

Gene Type: protein coding
Gene ID: 225865

Summary

Enables voltage-gated Calcium Channel activity. Acts upstream of or within several processes, including flagellated sperm motility; fusion of sperm to egg plasma membrane involved in single fertilization; and regulation of cilium beat frequency involved in ciliary motility. Located in plasma membrane. Part of CatSper complex. Is expressed in germ cell of testis; spermatid; spermatocyte; spermatozoon; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 7. Orthologous to human CATSPER1 (cation channel sperm associated 1). [provided by Alliance of Genome Resources, Apr 2022]

Catsper1 Products (1)

mRNA Protein Name
NM_139301.3 NP_647462.1 cation channel sperm-associated protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17227845 MGI
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
17478420 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
11595941 MGI
acts upstream of or within flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
11595941 MGI
acts upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization IMP
IMP: Inferred from mutant phenotype
11595941 MGI
acts upstream of or within regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
14657352 MGI
acts upstream of or within regulation of cilium beat frequency involved in ciliary motility IMP
IMP: Inferred from mutant phenotype
14657352 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
17478420 MGI
Cellular Component GO Annotation Evidence References Source
part of CatSper complex IDA
IDA: Inferred from direct assay
21224844 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11595941 MGI
located in sperm principal piece IDA
IDA: Inferred from direct assay
34225353 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cation channel sperm-associated protein 1

  • sperm calcium channel 1

  • sperm ion channel

  • sperm protein CATSPER1

Catsper1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Catsper1 Q91ZR5 Catsper3 Mus musculus Q80W99
Anti Bait CoIP
17227845
Intra
Catsper1 Q91ZR5 Catsper3 Mus musculus Q80W99
Anti Tag CoIP
17227845
Intra
Catsper1 Q91ZR5 Catsper4 Mus musculus Q8BVN3
Anti Bait CoIP
17227845
Intra
Catsper1 Q91ZR5 Catsper4 Mus musculus Q8BVN3
Anti Tag CoIP
17227845
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01984 CATSPER1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Catsper1 NCBI NCBI:117144