Npas4 - neuronal PAS domain protein 4 Gene

Also Known as Nxf; LE-PAS

Species: Mus musculus

Gene Type: protein coding
Gene ID: 225872

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including inhibitory synapse assembly; learning or memory; and modulation of chemical synaptic transmission. Acts upstream of or within cellular response to corticosterone stimulus; inhibitory postsynaptic potential; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in bladder; brain; embryo; ureter; and urethra of female. Orthologous to human NPAS4 (neuronal PAS domain protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Npas4 Products (1)

mRNA Protein Name
NM_153553.5 NP_705781.1 neuronal PAS domain-containing protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
18815592 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
14701734 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
24201284 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14701734 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
27782878 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to acid chemical IMP
IMP: Inferred from mutant phenotype
24201284 MGI
acts upstream of or within cellular response to corticosterone stimulus IDA
IDA: Inferred from direct assay
20626564 MGI
acts upstream of or within cellular response to stress IDA
IDA: Inferred from direct assay
20626564 MGI
involved in excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
24855953 MGI
acts upstream of or within inhibitory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
24201284 MGI
involved in inhibitory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
18815592 MGI
involved in inhibitory synapse assembly IMP
IMP: Inferred from mutant phenotype
18815592 MGI
involved in learning IMP
IMP: Inferred from mutant phenotype
22194569 MGI
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
22194569 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15363889 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18815592 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14701734 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18815592 MGI
involved in regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
18815592 MGI
involved in regulation of synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
18815592 MGI
involved in short-term memory IMP
IMP: Inferred from mutant phenotype
22194569 MGI
involved in social behavior IMP
IMP: Inferred from mutant phenotype
23029555 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15363889 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
14701734 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal PAS domain-containing protein 4

  • HLH-PAS transcription factor NXF

  • bHLH-PAS type transcription factor NXF

  • limbic-enhanced PAS protein

  • neuronal PAS4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09471 NPAS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npas4 NCBI NCBI:266743