Npas4 - neuronal PAS domain protein 4 Gene

Mus musculus

Also known as Nxf; LE-PAS

Gene ID: 225872 | Gene type: protein coding

About Npas4

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including inhibitory synapse assembly; learning or memory; and modulation of chemical synaptic transmission. Acts upstream of or within cellular response to corticosterone stimulus; inhibitory postsynaptic potential; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in bladder; brain; embryo; ureter; and urethra of female. Orthologous to human NPAS4 (neuronal PAS domain protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Npas4 Products(1)

mRNA	Protein	Name
NM_153553.5	NP_705781.1	neuronal PAS domain-containing protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	18815592	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14701734	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24201284	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14701734	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	27782878	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to acid chemical	IMP IMP: Inferred from mutant phenotype	24201284	MGI
acts upstream of or within cellular response to corticosterone stimulus	IDA IDA: Inferred from direct assay	20626564	MGI
acts upstream of or within cellular response to stress	IDA IDA: Inferred from direct assay	20626564	MGI
involved in excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	24855953	MGI
acts upstream of or within inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	24201284	MGI
involved in inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	18815592	MGI
involved in inhibitory synapse assembly	IMP IMP: Inferred from mutant phenotype	18815592	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	22194569	MGI
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	22194569	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15363889	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18815592	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14701734	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18815592	MGI
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	18815592	MGI
involved in regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	18815592	MGI
involved in short-term memory	IMP IMP: Inferred from mutant phenotype	22194569	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	23029555	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15363889	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	14701734	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuronal PAS domain-containing protein 4

HLH-PAS transcription factor NXF	bHLH-PAS type transcription factor NXF
limbic-enhanced PAS protein	neuronal PAS4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09471	NPAS4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Npas4	NCBI	NCBI:266743

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