NPAS4 - neuronal PAS domain protein 4 Gene

Also Known as NXF; Le-PAS; PASD10; bHLHe79

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 266743

About NPAS4

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,409,158-66,426,707 (from NCBI)

This gene has 4 transcripts (splice variants), 218 orthologues and 7 paralogues. Broad expression in brain (RPKM 1.7), endometrium (RPKM 1.7) and 14 other tissues.

Summary

NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008]

NPAS4 Products (2)

mRNA Protein Name
NM_001318804.1 NP_001305733.1 neuronal PAS domain-containing protein 4 isoform 2
NM_178864.4 NP_849195.2 neuronal PAS domain-containing protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
14701734 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
24465693 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
14701734 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24465693 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
24465693 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14701734 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPAS4 Protein Structure

PAS_3

PAS_3: PAS fold (229 - 296)

  • 0
  • 200
  • 400
  • 600
  • 802 a.a.
Protein Preferred Names Protein Names

neuronal PAS domain-containing protein 4

  • HLH-PAS transcription factor NXF

NPAS4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811077 NPAS4 Antibody WB, IHC-P, ICC/IF Human, Monkey

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09471 NPAS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NPAS4 MGD MGI:2664186
Macaca mulatta NPAS4 VGNC VGNC:75211
Rattus norvegicus NPAS4 RGD RGD:628866
Canis familiaris NPAS4 VGNC VGNC:43910
Bos taurus NPAS4 VGNC VGNC:32191
Felis catus NPAS4 VGNC VGNC:63865
Others NPAS4 NCBI