Epb41l5 - erythrocyte membrane protein band 4.1 like 5 Gene

Mus musculus

Also known as BE37; NBL5; Lulu1; Epb4.1l5; 1700030C16Rik; E230025E14Rik

Gene ID: 226352 | Gene type: protein coding

About Epb41l5

Summary

Enables protein domain specific binding activity. Involved in epithelial to mesenchymal transition. Acts upstream of or within several processes, including chordate embryonic development; embryonic foregut morphogenesis; and mesoderm morphogenesis. Located in focal adhesion and ruffle membrane. Is expressed in several structures, including foregut; lung; metanephros; neural tube; and primitive streak. Orthologous to human EPB41L5 (erythrocyte membrane protein band 4.1 like 5). [provided by Alliance of Genome Resources, Apr 2022]

Epb41l5 Products(2)

mRNA	Protein	Name
NM_001113416.1	NP_001106887.1	band 4.1-like protein 5 isoform 2
NM_145506.4	NP_663481.2	band 4.1-like protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18794329	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	18794329	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin cytoskeleton organization	IDA IDA: Inferred from direct assay	17507402	MGI
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	17507402	MGI
acts upstream of or within actomyosin structure organization	IDA IDA: Inferred from direct assay	20103536	MGI
acts upstream of or within apical constriction	IDA IDA: Inferred from direct assay	20103536	MGI
acts upstream of or within axial mesoderm development	IMP IMP: Inferred from mutant phenotype	15755804	MGI
acts upstream of or within axial mesoderm morphogenesis	IMP IMP: Inferred from mutant phenotype	17507402	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	20678497	MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	18794329	MGI
acts upstream of or within ectoderm development	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within embryonic foregut morphogenesis	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within epithelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	18794329	MGI
involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	17507402	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within left/right axis specification	IMP IMP: Inferred from mutant phenotype	20678497	MGI
acts upstream of or within mesoderm development	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within mesoderm migration involved in gastrulation	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within negative regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within negative regulation of protein binding	IDA IDA: Inferred from direct assay	18794329	MGI
acts upstream of or within neural plate morphogenesis	IMP IMP: Inferred from mutant phenotype	17507402	MGI
acts upstream of or within paraxial mesoderm development	IMP IMP: Inferred from mutant phenotype	15755804	MGI
acts upstream of or within positive regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within positive regulation of protein binding	IDA IDA: Inferred from direct assay	18794329	MGI
acts upstream of or within post-transcriptional regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within regulation of establishment of protein localization	IDA IDA: Inferred from direct assay	18794329	MGI
acts upstream of or within somite rostral/caudal axis specification	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within substrate-dependent cell migration, cell attachment to substrate	IMP IMP: Inferred from mutant phenotype	18794329	MGI
acts upstream of or within unidimensional cell growth	IDA IDA: Inferred from direct assay	20103536	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell leading edge	IDA IDA: Inferred from direct assay	18794329	MGI
located in focal adhesion	IDA IDA: Inferred from direct assay	18794329	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17920587	MGI
located in ruffle membrane	IDA IDA: Inferred from direct assay	18794329	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

band 4.1-like protein 5

erythrocyte protein band 4.1-like 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04416	EPB41L5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Epb41l5	NCBI	NCBI:57669

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