2. Gene
  3. Gigyf2 - GRB10 interacting GYF protein 2 Gene

Gigyf2 - GRB10 interacting GYF protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tnrc15; mKIAA0642; 2610016F01Rik; A830080H02Rik

Gene ID: 227331 | Gene type: protein coding

About Gigyf2

Summary

Predicted to enable proline-rich region binding activity. Acts upstream of or within several processes, including insulin-like growth factor receptor signaling pathway; mitotic G1 DNA damage checkpoint signaling; and spinal cord motor neuron differentiation. Located in several cellular components, including perikaryon; proximal dendrite; and vesicle. Is integral component of membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GIGYF2 (GRB10 interacting GYF protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Gigyf2 Products(2)

mRNA Protein Name
NM_001110212.2 NP_001103682.1 GRB10-interacting GYF protein 2 isoform b
NM_146112.4 NP_666224.3 GRB10-interacting GYF protein 2 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12771153 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
19744960 MGI
acts upstream of or within feeding behavior IMP
IMP: Inferred from mutant phenotype
19744960 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
19744960 MGI
acts upstream of or within insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19744960 MGI
acts upstream of or within mitotic G1 DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
19744960 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
19744960 MGI
acts upstream of or within musculoskeletal movement IMP
IMP: Inferred from mutant phenotype
19744960 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
19744960 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
19744960 MGI
acts upstream of or within protein metabolic process IMP
IMP: Inferred from mutant phenotype
19744960 MGI
acts upstream of or within spinal cord motor neuron differentiation IMP
IMP: Inferred from mutant phenotype
19744960 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20670374 MGI
located in membrane IDA
IDA: Inferred from direct assay
20670374 MGI
located in perikaryon IDA
IDA: Inferred from direct assay
20670374 MGI
located in proximal dendrite IDA
IDA: Inferred from direct assay
20670374 MGI
located in vesicle IDA
IDA: Inferred from direct assay
20670374 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GRB10-interacting GYF protein 2

PERQ amino acid-rich with GYF domain-containing protein 2

trinucleotide repeat containing 15

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05422 GIGYF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181617 12-Hydroxyfusicoccin / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gigyf2 NCBI NCBI:26058