Gigyf2 - GRB10 interacting GYF protein 2 Gene

Also Known as Tnrc15; mKIAA0642; 2610016F01Rik; A830080H02Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 227331

Summary

Predicted to enable proline-rich region binding activity. Acts upstream of or within several processes, including insulin-like growth factor receptor signaling pathway; mitotic G1 DNA damage checkpoint signaling; and spinal cord motor neuron differentiation. Located in several cellular components, including perikaryon; proximal dendrite; and vesicle. Is integral component of membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GIGYF2 (GRB10 interacting GYF protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Gigyf2 Products (2)

mRNA	Protein	Name
NM_001110212.2	NP_001103682.1	GRB10-interacting GYF protein 2 isoform b
NM_146112.4	NP_666224.3	GRB10-interacting GYF protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12771153	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	19744960	MGI
acts upstream of or within feeding behavior	IMP IMP: Inferred from mutant phenotype	19744960	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	19744960	MGI
acts upstream of or within insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19744960	MGI
acts upstream of or within mitotic G1 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	19744960	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	19744960	MGI
acts upstream of or within musculoskeletal movement	IMP IMP: Inferred from mutant phenotype	19744960	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	19744960	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	19744960	MGI
acts upstream of or within protein metabolic process	IMP IMP: Inferred from mutant phenotype	19744960	MGI
acts upstream of or within spinal cord motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	19744960	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20670374	MGI
located in membrane	IDA IDA: Inferred from direct assay	20670374	MGI
located in perikaryon	IDA IDA: Inferred from direct assay	20670374	MGI
located in proximal dendrite	IDA IDA: Inferred from direct assay	20670374	MGI
located in vesicle	IDA IDA: Inferred from direct assay	20670374	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
GRB10-interacting GYF protein 2	PERQ amino acid-rich with GYF domain-containing protein 2 trinucleotide repeat containing 15

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05422	GIGYF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181617	12-Hydroxyfusicoccin		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gigyf2	NCBI	NCBI:26058