Farp2 - FERM, RhoGEF and pleckstrin domain protein 2 Gene

Also Known as Fir; mKIAA0793; D030026M03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 227377

Summary

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including actin Cytoskeleton reorganization; osteoclast differentiation; and podosome assembly. Acts upstream of or within hair cycle process. Predicted to be located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Farp2 Products (1)

mRNA Protein Name
NM_145519.2 NP_663494.2 FERM, ARHGEF and pleckstrin domain-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
23375260 MGI
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
20702777 MGI
involved in cell adhesion IMP
IMP: Inferred from mutant phenotype
20702777 MGI
acts upstream of or within hair cycle process IMP
IMP: Inferred from mutant phenotype
25340873 MGI
involved in osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
20702777 MGI
involved in podosome assembly IMP
IMP: Inferred from mutant phenotype
20702777 MGI
involved in regulation of integrin activation IMP
IMP: Inferred from mutant phenotype
20702777 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
20702777 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

FERM, ARHGEF and pleckstrin domain-containing protein 2

  • FERM domain including RhoGEF

  • FERM, RhoGEF and pleckstrin domain-containing protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04747 FARP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Farp2 NCBI NCBI:9855