Farp2 - FERM, RhoGEF and pleckstrin domain protein 2 Gene

Mus musculus

Also known as Fir; mKIAA0793; D030026M03Rik

Gene ID: 227377 | Gene type: protein coding

About Farp2

Summary

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including actin Cytoskeleton reorganization; osteoclast differentiation; and podosome assembly. Acts upstream of or within hair cycle process. Predicted to be located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Farp2 Products(1)

mRNA	Protein	Name
NM_145519.2	NP_663494.2	FERM, ARHGEF and pleckstrin domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	23375260	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20702777	MGI
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	20702777	MGI
acts upstream of or within hair cycle process	IMP IMP: Inferred from mutant phenotype	25340873	MGI
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	20702777	MGI
involved in podosome assembly	IMP IMP: Inferred from mutant phenotype	20702777	MGI
involved in regulation of integrin activation	IMP IMP: Inferred from mutant phenotype	20702777	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	20702777	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

FERM, ARHGEF and pleckstrin domain-containing protein 2

FERM domain including RhoGEF

FERM, RhoGEF and pleckstrin domain-containing protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04747	FARP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Farp2	NCBI	NCBI:9855

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