Man1b1 - mannosidase, alpha, class 1B, member 1 Gene

Also Known as Gm108; ERMan1; MANA-ER; E430019H13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 227619

Summary

Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Acts upstream of or within ubiquitin-dependent ERAD pathway. Predicted to be located in cytoplasmic vesicle and endoplasmic reticulum quality control compartment. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MAN1B1 (mannosidase alpha class 1B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Man1b1 Products (1)

mRNA Protein Name
NM_001029983.2 NP_001025154.1 endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
IMP: Inferred from mutant phenotype
15294975 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ERAD pathway IMP
IMP: Inferred from mutant phenotype
15294975 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

  • ER alpha-1,2-mannosidase

  • ER mannosidase 1

  • man9GlcNAc2-specific-processing alpha-mannosidase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08006 MAN1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19789 Man1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26285 Man1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Man1b1 NCBI NCBI:11253