Dennd1a - DENN domain containing 1A Gene

Also Known as connecdenn; 6030446I19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 227801

Summary

Enables several functions, including SH3 domain binding activity; guanyl-nucleotide exchange factor activity; and phosphatidylinositol-3-phosphate binding activity. Involved in endocytic recycling and positive regulation of GTPase activity. Acts upstream of or within synaptic vesicle endocytosis. Located in several cellular components, including clathrin-coated vesicle membrane; dendrite; and neuronal cell body. Orthologous to human DENND1A (DENN domain containing 1A). [provided by Alliance of Genome Resources, Apr 2022]

Dennd1a Products (4)

mRNA Protein Name
NM_001362973.1 NP_001349902.1 DENN domain-containing protein 1A isoform 1
NM_001362977.1 NP_001349906.1 DENN domain-containing protein 1A isoform 3 precursor
NM_001362978.1 NP_001349907.1 DENN domain-containing protein 1A isoform 4 precursor
NM_146122.3 NP_666234.3 DENN domain-containing protein 1A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
17182770 MGI
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
20159556 MGI
enables phosphatidylinositol phosphate binding IDA
IDA: Inferred from direct assay
20159556 MGI
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
20159556 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17182770 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
20159556 MGI
Biological Process GO Annotation Evidence References Source
involved in endocytic recycling IDA
IDA: Inferred from direct assay
20159556 MGI
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
20159556 MGI
acts upstream of or within synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
17182770 MGI
Cellular Component GO Annotation Evidence References Source
located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
17182770 MGI
located in clathrin-coated vesicle membrane IDA
IDA: Inferred from direct assay
17182770 MGI
located in dendrite IDA
IDA: Inferred from direct assay
17182770 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
17182770 MGI
located in synapse IDA
IDA: Inferred from direct assay
17182770 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DENN domain-containing protein 1A

  • DENN/MADD domain containing 1A

  • connecdenn 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03685 DENND1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dennd1a NCBI NCBI:57706