Dennd1a - DENN domain containing 1A Gene

Mus musculus

Also known as connecdenn; 6030446I19Rik

Gene ID: 227801 | Gene type: protein coding

About Dennd1a

Summary

Enables several functions, including SH3 domain binding activity; guanyl-nucleotide exchange factor activity; and phosphatidylinositol-3-phosphate binding activity. Involved in endocytic recycling and positive regulation of GTPase activity. Acts upstream of or within synaptic vesicle endocytosis. Located in several cellular components, including clathrin-coated vesicle membrane; dendrite; and neuronal cell body. Orthologous to human DENND1A (DENN domain containing 1A). [provided by Alliance of Genome Resources, Apr 2022]

Dennd1a Products(4)

mRNA	Protein	Name
NM_001362973.1	NP_001349902.1	DENN domain-containing protein 1A isoform 1
NM_001362977.1	NP_001349906.1	DENN domain-containing protein 1A isoform 3 precursor
NM_001362978.1	NP_001349907.1	DENN domain-containing protein 1A isoform 4 precursor
NM_146122.3	NP_666234.3	DENN domain-containing protein 1A isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	17182770	MGI
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	20159556	MGI
enables phosphatidylinositol phosphate binding	IDA IDA: Inferred from direct assay	20159556	MGI
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	20159556	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17182770	MGI
enables small GTPase binding	IPI IPI: Inferred from physical interaction	20159556	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytic recycling	IDA IDA: Inferred from direct assay	20159556	MGI
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	20159556	MGI
acts upstream of or within synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	17182770	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	17182770	MGI
located in clathrin-coated vesicle membrane	IDA IDA: Inferred from direct assay	17182770	MGI
located in dendrite	IDA IDA: Inferred from direct assay	17182770	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	17182770	MGI
located in synapse	IDA IDA: Inferred from direct assay	17182770	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DENN domain-containing protein 1A

DENN/MADD domain containing 1A

connecdenn 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03685	DENND1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dennd1a	NCBI	NCBI:57706

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