Zp2 - zona pellucida glycoprotein 2 Gene

Mus musculus

Also known as Zp-2

Gene ID: 22787 | Gene type: protein coding

About Zp2

Summary

This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016]

Zp2 Products(2)

mRNA	Protein	Name
NM_001374631.1	NP_001361560.1	zona pellucida sperm-binding protein 2 isoform 2 preproprotein
NM_011775.7	NP_035905.1	zona pellucida sperm-binding protein 2 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11739644	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within binding of sperm to zona pellucida	IDA IDA: Inferred from direct assay	11739644	MGI
involved in binding of sperm to zona pellucida	IDA IDA: Inferred from direct assay	22472438	MGI
involved in prevention of polyspermy	IDA IDA: Inferred from direct assay	22472438	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	11906903	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17047254	MGI
located in multivesicular body	IDA IDA: Inferred from direct assay	17047254	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17047254	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zona pellucida sperm-binding protein 2

zona pellucida glycoprotein ZP2

zona pellucida protein A

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16187	ZP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zp2	NCBI	NCBI:7783

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