Zp2 - zona pellucida glycoprotein 2 Gene

Also Known as Zp-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22787

Summary

This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016]

Zp2 Products (2)

mRNA Protein Name
NM_001374631.1 NP_001361560.1 zona pellucida sperm-binding protein 2 isoform 2 preproprotein
NM_011775.7 NP_035905.1 zona pellucida sperm-binding protein 2 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11739644 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within binding of sperm to zona pellucida IDA
IDA: Inferred from direct assay
11739644 MGI
involved in binding of sperm to zona pellucida IDA
IDA: Inferred from direct assay
22472438 MGI
involved in prevention of polyspermy IDA
IDA: Inferred from direct assay
22472438 MGI
Cellular Component GO Annotation Evidence References Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
11906903 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
17047254 MGI
located in multivesicular body IDA
IDA: Inferred from direct assay
17047254 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17047254 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zona pellucida sperm-binding protein 2

  • zona pellucida glycoprotein ZP2

  • zona pellucida protein A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16187 ZP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zp2 NCBI NCBI:7783