Zp3 - zona pellucida glycoprotein 3 Gene

Also Known as Zp-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22788

Summary

Enables receptor ligand activity. A structural constituent of egg coat. Involved in several processes, including oogenesis; positive regulation of acrosome reaction; and regulation of gene expression. Acts upstream of or within binding activity of sperm to zona pellucida. Located in collagen-containing extracellular matrix and plasma membrane. Is expressed in ovary and testis. Orthologous to several human genes including ZP3 (zona pellucida glycoprotein 3). [provided by Alliance of Genome Resources, Apr 2022]

Zp3 Products (1)

mRNA Protein Name
NM_011776.1 NP_035906.1 zona pellucida sperm-binding protein 3 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7604284 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
10793136 MGI
enables receptor ligand activity IMP
IMP: Inferred from mutant phenotype
17258189 MGI
enables structural constituent of egg coat IMP
IMP: Inferred from mutant phenotype
14645511 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within binding of sperm to zona pellucida IDA
IDA: Inferred from direct assay
11739644 MGI
involved in binding of sperm to zona pellucida IGI
IGI: Inferred from genetic interaction
9609824 MGI
involved in binding of sperm to zona pellucida IMP
IMP: Inferred from mutant phenotype
11417900 MGI
acts upstream of or within binding of sperm to zona pellucida IPI
IPI: Inferred from physical interaction
9374408 MGI
involved in blastocyst formation IMP
IMP: Inferred from mutant phenotype
20382503 MGI
involved in egg coat formation IMP
IMP: Inferred from mutant phenotype
14645511 MGI
involved in humoral immune response mediated by circulating immunoglobulin IDA
IDA: Inferred from direct assay
20382503 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18667753 MGI
involved in oocyte development IMP
IMP: Inferred from mutant phenotype
18420282 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18667753 MGI
involved in positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
15579591 MGI
involved in positive regulation of acrosome reaction IDA
IDA: Inferred from direct assay
10793136 MGI
involved in positive regulation of antral ovarian follicle growth IMP
IMP: Inferred from mutant phenotype
18420282 MGI
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
18667753 MGI
involved in positive regulation of interleukin-4 production IDA
IDA: Inferred from direct assay
15579591 MGI
involved in positive regulation of leukocyte migration IDA
IDA: Inferred from direct assay
18667753 MGI
involved in positive regulation of ovarian follicle development IDA
IDA: Inferred from direct assay
18667753 MGI
involved in positive regulation of ovarian follicle development IMP
IMP: Inferred from mutant phenotype
15579591 MGI
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
15579591 MGI
involved in positive regulation of type IV hypersensitivity IDA
IDA: Inferred from direct assay
15579591 MGI
involved in regulation of signaling receptor activity IDA
IDA: Inferred from direct assay
10793136 MGI
involved in regulation of signaling receptor activity IMP
IMP: Inferred from mutant phenotype
17258189 MGI
Cellular Component GO Annotation Evidence References Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
11906903 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11417900 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zona pellucida sperm-binding protein 3

  • sperm receptor

  • zona pellucida glycoprotein ZP3

  • zona pellucida protein C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16188 ZP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17941 Zp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24412 Zp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zp3 NCBI NCBI:7784