P2rx3 - purinergic receptor P2X, ligand-gated ion channel, 3 Gene

Also Known as P2X3; 4930513E20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 228139

About P2rx3

Chromosome 2: 84,828,927-84,867,806 reverse strand.GRCm39:CM000995.3

This gene has 5 transcripts (splice variants), 275 orthologues, 6 paralogues and is associated with 4 phenotypes. Biased expression in testis adult (RPKM 11.8), CNS E14 (RPKM 1.5) and 2 other tissues.

Summary

Enables extracellularly ATP-gated cation channel activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within several processes, including neuromuscular synaptic transmission; response to ATP; and smooth muscle contraction. Located in Schaffer collateral - CA1 synapse and axon. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including branchial arch; embryo ectoderm; nervous system; retina; and skin. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Apr 2022]

P2rx3 Products (1)

mRNA Protein Name
NM_145526.2 NP_663501.2 P2X purinoceptor 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellularly ATP-gated monoatomic cation channel activity IGI
IGI: Inferred from genetic interaction
15081800 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral response to pain IGI
IGI: Inferred from genetic interaction
15961431 MGI
acts upstream of or within behavioral response to pain IMP
IMP: Inferred from mutant phenotype
11069181 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
17074061 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
11069181 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
17074061 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
17074061 MGI
acts upstream of or within monoatomic cation transport IMP
IMP: Inferred from mutant phenotype
11069182 MGI
acts upstream of or within monoatomic ion transport IMP
IMP: Inferred from mutant phenotype
11069181 MGI
acts upstream of or within neuromuscular synaptic transmission IMP
IMP: Inferred from mutant phenotype
12813150 MGI
acts upstream of or within peristalsis IMP
IMP: Inferred from mutant phenotype
12813150 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
17074061 MGI
acts upstream of or within response to ATP IGI
IGI: Inferred from genetic interaction
15961431 MGI
acts upstream of or within response to ATP IMP
IMP: Inferred from mutant phenotype
11069181 MGI
acts upstream of or within response to carbohydrate IMP
IMP: Inferred from mutant phenotype
16322458 MGI
acts upstream of or within response to cold IMP
IMP: Inferred from mutant phenotype
15927378 MGI
acts upstream of or within response to heat IMP
IMP: Inferred from mutant phenotype
15927378 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
14672995 MGI
acts upstream of or within response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
11466438 MGI
acts upstream of or within response to temperature stimulus IMP
IMP: Inferred from mutant phenotype
11069182 MGI
acts upstream of or within sensory perception of taste IGI
IGI: Inferred from genetic interaction
16322458 MGI
acts upstream of or within urinary bladder smooth muscle contraction IGI
IGI: Inferred from genetic interaction
15961431 MGI
acts upstream of or within urinary bladder smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
11069181 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
17074061 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
17074061 MGI
located in axon IDA
IDA: Inferred from direct assay
11466438 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
17074061 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: Inferred from mutant phenotype
17074061 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
11466438 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx3 Protein Structure

P2X_receptor

P2X_receptor: pfam00864 (7 - 359)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 3

  • ATP receptor

  • purinergic receptor P2X3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09903 P2RX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09904 P2rx3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09905 P2rx3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2rx3 NCBI NCBI:5024