P2RX3 - purinergic receptor P2X 3 Gene

Also Known as P2X3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5024

About P2RX3

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,335,950-57,372,396 (from NCBI)

This gene has 3 transcripts (splice variants), 275 orthologues and 6 paralogues. Biased expression in testis (RPKM 1.0), heart (RPKM 0.8) and 6 other tissues.

Summary

This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 Receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]

P2RX3 Products (7)

mRNA	Protein	Name
XR_949950.3
XM_011545069.3	XP_011543371.1	P2X purinoceptor 3 isoform X1
XM_011545073.2	XP_011543375.1	P2X purinoceptor 3 isoform X4
XM_011545071.3	XP_011543373.1	P2X purinoceptor 3 isoform X2
XM_011545072.3	XP_011543374.1	P2X purinoceptor 3 isoform X3
XM_011545070.3	XP_011543372.1	P2X purinoceptor 3 isoform X1
NM_002559.5	NP_002550.2	P2X purinoceptor 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables ATP binding	IDA IDA: Inferred from direct assay	27626375	GOA
enables extracellularly ATP-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	27626375	GOA
enables purinergic nucleotide receptor activity	IDA IDA: Inferred from direct assay	27626375	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cellular response to ATP	IDA IDA: Inferred from direct assay	27626375	GOA
involved in inorganic cation transmembrane transport	IDA IDA: Inferred from direct assay	27626375	GOA
involved in protein homotrimerization	IDA IDA: Inferred from direct assay	27626375	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	27626375	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RX3 Protein Structure

P2X_receptor

0
100
200
300
397 a.a.

Protein Preferred Names	Protein Names
P2X purinoceptor 3	ATP receptor P2X receptor, subunit 3 purinergic receptor P2X, ligand gated ion channel, 3 purinergic receptor P2X3 purinoceptor P2X3

Related Diseases

Diseases	Alias
Chronic Interstitial Cystitis
Migraine, Familial Hemiplegic, 1	FHM1 Mhp1 Fhm Familial Hemiplegic Migraine 1 Migraine, Familial Hemiplegic, 1, With Progressive Cerebellar Ataxia Familial Hemiplegic Migraine1 With Progressive Cerebellar Ataxia Migraine Familial Hemiplegic With Progressive Cerebellar Ataxia Migraine, Hemiplegic, Familial, Type 1 Hemiplegic Migraine, Familial Type 1
Migraine With Aura	Classic Migraine Migraine With Typical Aura Migraine Accompagnée Complicated Migraine Classical Migraine Acute Migraine With Aura
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Paine Syndrome	Pain Disorder Pain Microcephaly With Spastic Diplegia Pain Syndrome
Deafness, Autosomal Dominant 41	DFNA41 Autosomal Dominant Nonsyndromic Deafness 41 Autosomal Dominant Deafness 41 Deafness, Autosomal Dominant, 41 Deafness, Autosomal Dominant, Type 41
Reflex Sympathetic Dystrophy	Algodystrophy Complex Regional Pain Syndrome Type 1 Reflex Sympathetic Dystrophy Syndrome Complex Regional Pain Syndromes Algodystrophic Syndrome
Trigeminal Neuralgia	Tic Douloureux Trifacial Neuralgia Trifocal Neuralgia Neuralgia Of The Fifth Cranial Nerve Neuralgia Of 5th Cranial Nerve Infraorbital Neuralgia
Complex Regional Pain Syndrome	Complex Regional Pain Syndromes Reflex Sympathetic Dystrophy Crps
Chronic Pain
Urethral Syndrome	Urethral Disease Urethral Diseases Urethra Disease Abnormality Of The Urethra Urethral Disorders
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Erythromelalgia	Primary Erythromelalgia Erythermalgia Primary Erythermalgia Mitchell Disease Familial Erythromelalgia
Alcoholic Neuropathy	Alcoholic Polyneuropathy Alcohol-Related Polyneuropathy Alcohol-Induced Polyneuropathy Alcoholic Peripheral Neuropathy
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Femoral Cancer	Femoral Neoplasms Cancer Of The Femur Femoral Neoplasm Neoplasm Of Femur
Fibromyalgia	Diffuse Myofascial Pain Syndrome Fibromyalgia Syndrome Fibromyalgia-Fibromyositis Syndrome Fibromyositis Fibrositis Fms Myofascial Pain Syndrome Myofascial Pain Syndromes
Glossopharyngeal Neuralgia	Glossopharyngeal Nerve Diseases
Ischemic Neuropathy	Ischemic Peripheral Neuropathy
Familial Hemiplegic Migraine	Hemiplegic Migraine, Familial Hemiplegic-Ophthalmoplegic Migraine Fhm Hemiplegic Migraine Familial
Burning Mouth Syndrome	Orodynia Stomatodynia Stomatopyrosis Bms Burning Mouth Disorder Oral Dysesthesia Sore Mouth Syndrome Bms - [Burning Mouth Syndrome]
Cystitis	Infective Cystitis Urocystitis Pyocystitis
Trigeminal Nerve Disease	Trigeminal Nerve Diseases Disorders Of 5th Cranial Nerve Disorders Of The Fifth Cranial Nerve
Chronic Cystitis
Cough Variant Asthma
Somatoform Disorder	Physiological Malfunction Arising From Mental Factor Psychosomatic Disorder Psychophysiologic Disorders
Neurogenic Bladder	Neurogenic Dysfunction Of The Urinary Bladder Neurogenic Urinary Bladder Disorder Neuropathic Bladder Bladder Neurogenic Urinary Bladder, Neurogenic Neurogenic Urinary Bladder
Low Compliance Bladder	Overactive Bladder Hyperactivity Of Bladder Hypertonic Bladder Hypertonicity Of Bladder Low Bladder Compliance Oab - [Overactive Bladder]
Pain Agnosia	Analgesia
Detrusor Sphincter Dyssynergia	Detrusor And Sphincter Dyssynergia
Interstitial Cystitis	Bladder Pain Syndrome Painful Bladder Syndrome Ulcerative Cystitis Ic/Bps Ic/Pbs Interstitial Cystitis/Bladder Pain Syndrome Interstitial Cystitis/Painful Bladder Syndrome Cystitis, Interstitial Chronic Interstitial Cystitis Pelvic Congestion Syndrome Trigonitis
Myofascial Pain Syndrome	Myofascial Pain Syndromes Myofascial Pain Dysfunction Syndrome Fibromyalgia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS09903	P2RX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09904	P2rx3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09905	P2rx3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	P2RX3	RGD	RGD:620253
Felis catus	P2RX3	VGNC	VGNC:68670
Bos taurus	P2RX3	VGNC	VGNC:32519
Canis familiaris	P2RX3	VGNC	VGNC:44209
Mus musculus	P2RX3	MGD	MGI:1097160
Macaca mulatta	P2RX3	VGNC	VGNC:75733
Others	P2RX3	NCBI