Madd - MAP-kinase activating death domain Gene

Also Known as IG20; RabGEF; Rab3GEP; 9630059K23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 228355

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in anterograde synaptic vesicle transport; execution phase of apoptosis; and regulation of cell cycle. Acts upstream of or within negative regulation of apoptotic signaling pathway. Predicted to be located in nucleus; plasma membrane; and synaptic vesicle. Predicted to be integral component of membrane. Predicted to be active in cytosol. Is expressed in nervous system; sensory organ; and tongue. Used to study type 2 diabetes mellitus. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Apr 2022]

Madd Products (3)

mRNA Protein Name
NM_001177719.1 NP_001171190.1 MAP kinase-activating death domain protein isoform 10
NM_001177720.1 NP_001171191.1 MAP kinase-activating death domain protein isoform 11
NM_145527.4 NP_663502.3 MAP kinase-activating death domain protein isoform 9

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in anterograde synaptic vesicle transport IDA
IDA: Inferred from direct assay
18849981 MGI
involved in anterograde synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
18849981 MGI
involved in execution phase of apoptosis IMP
IMP: Inferred from mutant phenotype
14735464 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
14735464 MGI
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
14735464 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MAP kinase-activating death domain protein

  • Rab3 GDP/GTP exchange protein

  • Rab3 GEP

  • insulinoma-glucagonoma protein 20

  • rab3 GDP/GTP exchange factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-G0016 N-Acetyl dapsone / Unkown
HY-RS04555 ETFA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04556 ETFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04557 ETFDH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07953 MADD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Madd NCBI NCBI:8567